Górski Bartłomiej, Górska Renata
Department of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, Warsaw, Poland.
Cent Eur J Immunol. 2018;43(4):442-452. doi: 10.5114/ceji.2018.81356. Epub 2018 Dec 31.
The aim of this study was to analyze whether periodontal treatment affects the cardiovascular risk profile of patients after myocardial infarction (MI).
The study included 30 patients with chronic periodontitis (ChP). Sociodemographic and medical variables were collected. Patients were provided with scaling and root planing (SRP) 3 months after MI (1 visit). Periodontal examination and blood tests were performed immediately before SRP, then 1 month and 6 months after treatment (2 and 3 visit, respectively).
A statistically significant decrease in blood hsCRP concentration and a decrease in the number of white blood cells (WBC) and neutrophils between the first and the second visit were observed. At 6 months after SRP, the mean platelet volume (MPV) had increased with respect to the value at 1 month after treatment. Multivariate analysis showed that the associations between: 1) change in LDL-C concentration and change in approximal plaque index value (b = -0.546, p = 0.005); 2) change in the number of monocytes and change in the plaque index value (b = 0.616, p = 0.01); 3) change in MPV and change in probing pocket depth (b = 0.567, p = 0.018) are all independent of the classic cardiovascular risk factors.
The obtained results indicate the existence of a relationship between the state of periodontal tissues on one hand and mediators of atherosclerosis and the number of immunologically competent cells on the other hand.
本研究旨在分析牙周治疗是否会影响心肌梗死（MI）患者的心血管风险状况。
该研究纳入了30例慢性牙周炎（ChP）患者。收集了社会人口统计学和医学变量。患者在心肌梗死后3个月接受了龈上洁治和根面平整（SRP）（1次就诊）。在SRP前、治疗后1个月和6个月（分别为第2次和第3次就诊）进行了牙周检查和血液检测。
观察到第一次和第二次就诊之间血液中hsCRP浓度有统计学意义的下降，白细胞（WBC）和中性粒细胞数量减少。在SRP后6个月，平均血小板体积（MPV）相对于治疗后1个月的值有所增加。多变量分析表明：1）低密度脂蛋白胆固醇（LDL-C）浓度变化与邻面菌斑指数值变化之间的关联（b = -0.546，p = 0.005）；2）单核细胞数量变化与菌斑指数值变化之间的关联（b = 0.616，p = 0.01）；3）MPV变化与探诊深度变化之间的关联（b = 0.567，p = 0.018）均独立于经典心血管危险因素。
所得结果表明，一方面牙周组织状态与另一方面动脉粥样硬化介质和免疫活性细胞数量之间存在关联。
