Wang Xian'e, Meng Huanxin, Xu Li, Chen Zhibin, Shi Dong, Lv Da
Department of Periodontology, Peking University School and Hospital of Stomatology , Beijing , China.
Platelets. 2015;26(1):67-71. doi: 10.3109/09537104.2013.875137. Epub 2014 Feb 5.
Periodontitis has become the leading cause of tooth loss in adults, and the host's immunologic and inflammatory response to the bacteria can lead to periodontal destruction. In patients with periodontitis, platelets possess an increased activation status compared with platelets from healthy controls. Mean platelet volume (MPV) has been considered an important index of platelet activity and an inflammatory marker in many infectious diseases. The present study investigated the relationship between MPV and disease activity in subjects with severe periodontitis. Forty-five patients with periodontitis and 45 age and sex-matched healthy subjects were enrolled into the study. All subjects received periodontal and hematological examinations. The periodontitis patients were administered active periodontal treatment (APT). At baseline, a statistically significant decrease in MPV was noted in patients with periodontitis (9.73 ± 1.06 fL) compared with healthy controls (10.24 ± 1.07 fL). At 1 month post-APT, MPV was substantially increased (10.11 ± 1.04 fL). Positive correlation was found between increase of MPV and decrease of periodontal probing depth after treatment(r = 0.377; p = 0.014). In conclusion, the decrease of MPV was related to the severe periodontal inflammation, and the value inversed shift after APT. MPV might reflect the disease activity of periodontitis.
牙周炎已成为成年人牙齿缺失的主要原因，宿主对细菌的免疫和炎症反应可导致牙周组织破坏。与健康对照者的血小板相比，牙周炎患者的血小板具有更高的激活状态。平均血小板体积（MPV）被认为是血小板活性的重要指标以及许多传染病中的炎症标志物。本研究调查了重度牙周炎患者中MPV与疾病活动度之间的关系。45例牙周炎患者和45例年龄及性别匹配的健康受试者纳入本研究。所有受试者均接受了牙周和血液学检查。对牙周炎患者进行了积极的牙周治疗（APT）。基线时，与健康对照者（10.24±1.07 fL）相比，牙周炎患者的MPV有统计学意义的降低（9.73±1.06 fL）。APT后1个月，MPV显著升高（10.11±1.04 fL）。治疗后MPV的升高与牙周探诊深度的降低呈正相关（r = 0.377；p = 0.014）。总之，MPV的降低与重度牙周炎症有关，APT后该值反向变化。MPV可能反映牙周炎的疾病活动度。
