Djani Dylan M, Draper William E
VCA Animal Specialty Center of South Carolina, Columbia, SC, USA.
JFMS Open Rep. 2019 Feb 18;5(1):2055116919830214. doi: 10.1177/2055116919830214. eCollection 2019 Jan-Jun.
A 3-year-old spayed female domestic shorthair cat developed a fever 1 week after starting the anticonvulsant phenobarbital. A diagnostic work-up for seizures and subsequent onset of fever of unknown origin, consisting of MRI of the brain, cerebrospinal fluid analysis and infectious disease testing, was unremarkable. The cat was switched from phenobarbital onto pregabalin with complete resolution of the fever within 24 h, consistent with a drug-induced fever following phenobarbital administration.
While anticonvulsant hypersensitivities have been reported and studied in veterinary medicine, phenobarbital-induced fever outside of the context of systemic clinical signs has not been documented in the veterinary scientific literature. Drug-induced fever secondary to anticonvulsants should be considered in patients that develop a fever after starting anticonvulsant therapy with an unrewarding diagnostic work-up for fever of unknown origin.
一只3岁已绝育的雌性家养短毛猫在开始服用抗惊厥药物苯巴比妥1周后出现发热。针对癫痫发作及随后不明原因发热进行的诊断性检查，包括脑部磁共振成像（MRI）、脑脊液分析和传染病检测，均无异常发现。该猫从苯巴比妥换用普瑞巴林后，发热在24小时内完全消退，这与服用苯巴比妥后药物性发热相符。
虽然在兽医学中已报道并研究了抗惊厥药物超敏反应，但在兽医科学文献中，尚未记录在无全身临床症状情况下苯巴比妥引起的发热。对于开始抗惊厥治疗后出现发热且针对不明原因发热的诊断性检查无结果的患者，应考虑抗惊厥药物继发的药物性发热。
