Lieser J, Schwedes C S
AniCura Kleintierspezialisten Augsburg, 86157, Augsburg, Germany.
J Small Anim Pract. 2018 Jul;59(7):444-447. doi: 10.1111/jsap.12693. Epub 2017 Jun 29.
A two-year-old female spayed domestic shorthair cat was presented with apathy, inappetence and generalised lymphadenomegaly. Anamnestic data included a generalised seizure disorder and phenobarbital treatment started one month before presentation. Routine blood analysis revealed only mild abnormalities and FeLV and FIV tests were negative. Both popliteal lymph nodes were aspirated and cytology was consistent with reactive lymph node hyperplasia. PCR for antigen receptor rearrangement testing diagnosed a polyclonal cell population. In the absence of another cause, lymphadenomegaly was attributed to an adverse drug reaction and phenobarbital was discontinued. The cat's condition improved and lymph node size normalised over the next 10 days. The retrospective diagnosis was phenobarbital-induced pseudolymphoma.
一只两岁已绝育的雌性家养短毛猫出现精神萎靡、食欲不振和全身淋巴结肿大。既往病史包括全身性癫痫发作障碍，在就诊前一个月开始使用苯巴比妥治疗。常规血液分析仅显示轻度异常，猫白血病病毒（FeLV）和猫免疫缺陷病毒（FIV）检测均为阴性。双侧腘淋巴结进行了穿刺抽吸，细胞学检查结果符合反应性淋巴结增生。抗原受体重排检测的聚合酶链反应（PCR）诊断为多克隆细胞群。在没有其他病因的情况下，淋巴结肿大归因于药物不良反应，遂停用苯巴比妥。在接下来的10天里，猫的病情有所改善，淋巴结大小恢复正常。回顾性诊断为苯巴比妥诱发的假性淋巴瘤。
