孕期治疗药物、酒精和香烟使用情况的前瞻性调查。
Prospective survey of use of therapeutic drugs, alcohol, and cigarettes during pregnancy.
作者信息
Rubin P C, Craig G F, Gavin K, Sumner D
出版信息
Br Med J (Clin Res Ed). 1986 Jan 11;292(6513):81-3. doi: 10.1136/bmj.292.6513.81.
Use of drugs during pregnancy was recorded prospectively in 2765 women attending the antenatal clinics of a general hospital from October 1982 to March 1984. Of these women, 2588 (93.6%) avoided exposure to drugs during the first trimester, 1802 (65.2%) took no drugs at any stage, 963 (34.8%) took a total of 154 different drugs from 35 groups of drugs, and 243 (8.8%) took a self administered drug. The most commonly used drugs were non-narcotic analgesics, usually self administered, and antibacterials. The last survey of use of drugs in pregnancy in the United Kingdom 20 years ago showed fewer women avoiding drugs throughout pregnancy (195 of 911 (21.4%), p less than 0.001) and in taking a self administered drug (586 (64.4%), p less than 0.001) than at present. Most women nowadays abstain totally from alcohol (1786 (64.6%) v 109 (12.0%) previously, p less than 0.001), but while more women are non-smokers compared with previously (1811 (65.5%) v 392 (43%), p less than 0.001) the trend has been far less dramatic than that for use of alcohol.
1982年10月至1984年3月期间，对一家综合医院产前门诊的2765名孕妇使用药物的情况进行了前瞻性记录。在这些孕妇中，2588名（93.6%）在孕早期避免接触药物，1802名（65.2%）在任何阶段都未用药，963名（34.8%）总共使用了来自35类药物的154种不同药物，243名（8.8%）使用了自行服用的药物。最常用的药物是非麻醉性镇痛药（通常为自行服用）和抗菌药物。20年前英国上一次关于孕期用药的调查显示，与目前相比，整个孕期避免用药的女性较少（911名中的195名（21.4%），p<0.001），且使用自行服用药物的女性较少（586名（64.4%），p<0.001）。如今，大多数女性完全戒酒（1786名（64.6%）对之前的109名（12.0%），p<0.001），但与之前相比，虽然不吸烟的女性更多（1811名（65.5%）对392名（43%），p<0.001），但其趋势远不如饮酒情况那么显著。
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