介观受限抗癌药物与金属有机框架的太赫兹动力学暴露的主体-客体相互作用。
Guest-host interactions of nanoconfined anti-cancer drug in metal-organic framework exposed by terahertz dynamics.
机构信息
Multifunctional Materials and Composites (MMC) Laboratory, Department of Engineering Science, University of Oxford, Parks Road, Oxford, OX1 3PJ, UK.
出版信息
Chem Commun (Camb). 2019 Mar 28;55(27):3868-3871. doi: 10.1039/c8cc10089f.
PMID:30801075
Abstract
A facile mechanochemical method was employed to accomplish one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU as guest) in a metal-organic framework (HKUST-1 as host). Vibrational spectroscopy via inelastic neutron scattering was applied to probe guest-host interactions arising from nanoscale confinement. We compare 5-FU@HKUST-1 derived from in situ and ex situ encapsulation.
摘要
采用简便的机械化学方法，在金属有机骨架（HKUST-1 作为主体）中实现了抗癌药物 5-氟尿嘧啶（5-FU 作为客体）的一锅封装。通过非弹性中子散射的振动光谱来探测纳米限域引起的客体-主体相互作用。我们比较了原位和异位封装得到的 5-FU@HKUST-1。
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