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[肾小球源性急性肾衰竭]

[Acute renal failure of glomerular origin].

作者信息

Thervet Éric

机构信息

Service de néphrologie, département hypertension artérielle, prévention et prise en charge des affections rénales et cardiovasculaires, Hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, université Paris-Descartes Paris, France.

出版信息

Rev Prat. 2018 Feb;68(2):160-165.

Abstract

Acute renal failure of glomerular origin. Glomerulopathies account for about 10% of acute kidney injury (AKI) in adults. They often require urgent care. The clinico-biological presentations are acute nephritic syndrome (GNA) and rapidly progressive glomerulonephritis. GNA combines an organic AKI with signs of sodium retention. The most commonly found germs are streptococci, staphylococci and Escherichia coli. Rapidly progressive glomerulonephritis is characterized by a renal failure that settles in a few weeks, with marked hematuria. Blood tests depend of the context but include complement study and ANCA. Histologically, extracapillary lesions are present with various immunoglobulin deposits.

摘要

肾小球源性急性肾衰竭。肾小球疾病约占成人急性肾损伤(AKI)的10%。它们通常需要紧急治疗。临床生物学表现为急性肾炎综合征(GNA)和急进性肾小球肾炎。GNA合并器质性AKI及钠潴留体征。最常见的病原体是链球菌、葡萄球菌和大肠杆菌。急进性肾小球肾炎的特征是在几周内出现肾衰竭,并伴有明显血尿。血液检查取决于具体情况,但包括补体研究和抗中性粒细胞胞浆抗体(ANCA)。组织学上,存在毛细血管外病变及各种免疫球蛋白沉积。

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