School of Chinese Medicine , Beijing University of Chinese Medicine , Beijing 100029 , China.
Department of Radiology, Peking Union Medical College Hospital , Chinese Academy of Medical Sciences , Beijing 100730 , China.
ACS Appl Mater Interfaces. 2019 Mar 20;11(11):10452-10461. doi: 10.1021/acsami.8b18648. Epub 2019 Mar 11.
Iron deficiency anemia (IDA) is a common nutritional disease suffered by 1 billion people. To develop a new drug which avoids the side effects of traditional oral iron supplementation for IDA treatment, we have designed FeO@ Astragalus polysaccharide core-shell nanoparticles (FeO@APS NPs) and demonstrated them to be an efficient therapeutic drug for IDA treatment in vivo. The FeO@APS NPs have been successfully synthesized with good water solubility and stability, especially in imitated digestion. Cytotoxicity assessment in cells and pathological tests in mice justify their good biocompatibility and low toxicity. The IDA treatment in rats shows that they have efficient therapeutic effect, which is contributed to both the iron element supplement from FeO and the APS-stimulated hematopoietic cell generation. Moreover, the superparamagnetic FeO@APS NPs are capable for use as a magnetic resonance imaging contrast agent. This study presents the possibility of nanocomposites involving purified natural products from Chinese herb medicine for biomedical applications.
缺铁性贫血（IDA）是一种常见的营养性疾病，影响全球 10 亿人。为避免传统口服铁补充剂治疗 IDA 的副作用，我们设计了 FeO@黄芪多糖核壳纳米粒子（FeO@APS NPs），并证明其在体内对 IDA 具有高效的治疗作用。FeO@APS NPs 已成功合成，具有良好的水溶性和稳定性，特别是在模拟消化过程中。细胞毒性评估和小鼠病理学试验证明了其良好的生物相容性和低毒性。在大鼠的 IDA 治疗中表明，它们具有高效的治疗效果，这归因于 FeO 提供的铁元素和 APS 刺激造血细胞生成两方面。此外，超顺磁 FeO@APS NPs 可用作磁共振成像造影剂。该研究为涉及中药中纯化天然产物的纳米复合材料用于生物医学应用提供了可能性。
