Nano-Biotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia.
Nano-Optoelectronics Research and Technology Lab (NORLab), School of Physics, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia.
Sci Rep. 2020 Jul 1;10(1):10793. doi: 10.1038/s41598-020-67869-8.
A highly stable and magnetized citric acid (CA)-functionalized iron oxide aqueous colloidal solution (FeO@CA) was synthesized by using a simple and rapid method of one-step co-participation via a chemical reaction between Fe and Fe in a NaOH solution at 65 °C, followed by CA addition to functionalize the FeO surface in 25 min. The NPs were synthesized at lower temperatures and shortened time compared with conventional methods. Surface functionalization is highly suggested because bare FeO nanoparticles (FeO NPs) are frequently deficient due to their low stability and hydrophilicity. Hence, 19 nm-sized FeO NPs coated with CA (FeO@CA) were synthesized, and their microstructure, morphology, and magnetic properties were characterized using X-ray diffraction, transmission electron microscopy, Zeta potential, Fourier transform infrared spectroscopy, and vibrating sample magnetometer. CA successfully modified the FeO surface to obtain a stabilized (homogeneous and well dispersed) aqueous colloidal solution. The Zeta potential value of the as-prepared FeO@CA increases from - 31 to - 45 mV. These CA-functionalized NPs with high magnetic saturation (54.8 emu/g) show promising biomedical applications.
一种高度稳定且可磁化的柠檬酸（CA）功能化氧化铁水胶体溶液（FeO@CA），是通过在 65°C 的 NaOH 溶液中 Fe 和 Fe 之间的一步共参与化学反应，然后在 25 分钟内添加 CA 来功能化 FeO 表面，从而使用简单快速的一步法合成的。与传统方法相比，纳米颗粒的合成温度更低，时间更短。强烈建议进行表面功能化，因为由于其低稳定性和亲水性，裸露的氧化铁纳米颗粒（FeO NPs）经常不足。因此，合成了 CA（FeO@CA）包覆的 19nm 尺寸的 FeO NPs，并使用 X 射线衍射、透射电子显微镜、Zeta 电位、傅里叶变换红外光谱和振动样品磁强计对其微观结构、形貌和磁性进行了表征。CA 成功地修饰了 FeO 表面，获得了稳定的（均匀且分散良好的）水胶体溶液。所制备的 FeO@CA 的 Zeta 电位值从-31mV 增加到-45mV。这些具有高饱和磁化强度（54.8 emu/g）的 CA 功能化 NPs 在生物医学应用中具有广阔的前景。
