Xiao Han-Zhi, Wang Wen-Shu, Sun Yu-Song, Luo Hao, Li Bo-Wen, Wang Xiao-Dong, Lin Wei-Li, Luo Fei-Xian
College of Life and Environment Science , §MUC Center on Translational Neuroscience , and ¶Experimental Center of Chemistry , Minzu University of China , Beijing 100081 , China.
Org Lett. 2019 Mar 15;21(6):1668-1671. doi: 10.1021/acs.orglett.9b00214. Epub 2019 Feb 25.
In this letter, we successfully explored a cascade Pd/Cu-catalyzed intermolecular C(sp)-H arylation of amides and intramolecular C-N coupling reaction. This method provides a one-pot strategy to synthesize 3,4-2 H-quinolinone with good regioselectivity of C-H arylation and C-N coupling from C-I and C-X bonds from readily available starting materials.
在本信函中，我们成功探索了一种级联钯/铜催化的酰胺分子间C(sp)-H芳基化反应和分子内C-N偶联反应。该方法提供了一种一锅法策略，可从易得的起始原料的C-I键和C-X键出发，以良好的C-H芳基化和C-N偶联区域选择性合成3,4-二氢喹啉酮。
