铜/钯协同催化不饱和酰胺的串联分子内反马氏氢芳基化反应：通过硼化/分子内C(sp)-C(sp)交叉偶联轻松构建3,4-二氢喹啉酮
Cu/Pd cooperatively catalyzed tandem intramolecular anti-Markovnikov hydroarylation of unsaturated amides: facile construction of 3,4-dihydroquinolinones via borylation/intramolecular C(sp)-C(sp) cross coupling.
作者信息
Kuang Zhijie, Li Bingnan, Song Qiuling
机构信息
Institute of Next Generation Matter Transformation, College of Chemical Engineering, College of Material Sciences Engineering, Huaqiao University, Xiamen, Fujian 361021, China.
出版信息
Chem Commun (Camb). 2017 Dec 19;54(1):34-37. doi: 10.1039/c7cc07180a.
An anti-Markovnikov hydroarylation of unsaturated amides via a Cu/Pd synergistically catalyzed cascade borylation/intramolecular sp-sp cross-coupling has been disclosed. 3,4-Dihydroquinolinones, one type of important scaffold prevailing in pharmaceuticals and biologically active compounds, could be readily accessible with high regio-selectivity and high yields.
已公开了一种通过铜/钯协同催化的级联硼化/分子内sp-sp交叉偶联实现的不饱和酰胺的反马氏氢芳基化反应。3,4-二氢喹啉酮是一类在药物和生物活性化合物中普遍存在的重要骨架，可通过该反应以高区域选择性和高收率轻松获得。
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