尼古丁和苯环己哌啶对大鼠50千赫兹发声声学特征的改变。
Alterations of acoustic features of 50 kHz vocalizations by nicotine and phencyclidine in rats.
作者信息
Swalve Natashia, Mulholland Michele M, Li Ming
机构信息
Department of Psychology, Alma College, Alma, Michigan.
Department of Psychology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
出版信息
Behav Pharmacol. 2019 Aug;30(5):446-451. doi: 10.1097/FBP.0000000000000463.
Ultrasonic vocalizations are widely used to examine affective states in rats, yet relatively few studies explore the acoustic features of vocalizations, especially in relation to drug exposure, and no studies have explored alterations in acoustic features over time. The goal of this study was to examine nicotine- and phencyclidine-induced alterations of bandwidth, duration, and frequency of 50 kHz vocalizations. The minimum and maximum frequency, bandwidth, and duration of calls were examined after 7 days of daily subcutaneous administration of phencyclidine (2.0 mg/kg) and nicotine (0.2 and 0.4 mg/kg) in male Sprague-Dawley rats. Bandwidth was significantly decreased in rats treated with both nicotine (0.2 and 0.4 mg/kg) and phencyclidine. Maximum frequency was lowest on the first day of exposure compared with all other days and was not altered by drug exposure. Call duration was not affected by time or drug exposure. These findings suggest the importance of studying alterations in acoustic features in time, especially those induced by drug exposure.
超声波发声被广泛用于检测大鼠的情绪状态，但相对较少的研究探讨发声的声学特征，尤其是与药物暴露相关的特征，且尚无研究探讨声学特征随时间的变化。本研究的目的是检测尼古丁和苯环利定诱导的50kHz发声的带宽、持续时间和频率的变化。在雄性斯普拉-道利大鼠中，每日皮下注射苯环利定（2.0mg/kg）和尼古丁（0.2mg/kg和0.4mg/kg）7天后，检测叫声的最低和最高频率、带宽及持续时间。尼古丁（0.2mg/kg和0.4mg/kg）和苯环利定处理的大鼠的带宽均显著降低。与所有其他天数相比，暴露第一天的最高频率最低，且不受药物暴露影响。叫声持续时间不受时间或药物暴露影响。这些发现表明及时研究声学特征变化的重要性，尤其是药物暴露引起的变化。
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