2nd Department of Internal Medicine, Faculty of Medicine.
MTA-SE Molecular Medicine Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.
Curr Opin Endocrinol Diabetes Obes. 2019 Jun;26(3):155-159. doi: 10.1097/MED.0000000000000472.
Circulating microRNAs represent promising minimally invasive markers of several diseases including tumors. As the preoperative diagnosis of different adrenal tumors is difficult, for example, diagnosis of adrenocortical or adrenomedullary malignancy, circulating microRNAs might be helpful in their clinical management.
Observations regarding the applicability of circulating microRNAs isolated both from unfractionated plasma or serum and from extracellular vesicle preparations for the diagnosis of adrenocortical malignancy have been published. Data show that circulating microRNA might be exploited for monitoring adrenocortical cancer progression. Circulating microRNA profiles of adrenal myelolipoma have also been published that might be useful for differentiating adrenocortical cancer and adrenal myelolipoma in dubious cases.
In this review, recent advances in the field of circulating microRNAs in adrenal tumors are discussed.
循环 microRNAs 是几种疾病（包括肿瘤）有前途的微创标志物。由于不同肾上腺肿瘤的术前诊断较为困难，例如，肾上腺皮质或肾上腺髓质恶性肿瘤的诊断，循环 microRNAs 可能有助于其临床管理。
已经发表了关于从未分级的血浆或血清以及从细胞外囊泡制剂中分离的循环 microRNAs 用于诊断肾上腺皮质恶性肿瘤的适用性的观察结果。数据表明，循环 microRNA 可用于监测肾上腺皮质癌的进展。还发表了肾上腺髓样脂肪瘤的循环 microRNA 图谱，这可能有助于在可疑病例中区分肾上腺皮质癌和肾上腺髓样脂肪瘤。
本文讨论了肾上腺肿瘤中循环 microRNAs 领域的最新进展。
