肾上腺皮质癌中的非编码RNA：从发病机制到诊断
Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis.
作者信息
Decmann Abel, Perge Pál, Turai Peter Istvan, Patócs Attila, Igaz Peter
机构信息
2nd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi Str. 46., H-1088 Budapest, Hungary.
MTA-SE Lendület Hereditary Endocrine Tumors Research Group, H-1089 Budapest, Hungary.
出版信息
Cancers (Basel). 2020 Feb 17;12(2):461. doi: 10.3390/cancers12020461.
Non-coding RNA molecules including microRNAs and long non-coding RNAs (lncRNA) have been implicated in the pathogenesis of several tumors and numerous data support their applicability in diagnosis as well. Despite recent advances, the pathogenesis of adrenocortical cancer still remains elusive and there are no reliable blood-borne markers of adrenocortical malignancy, either. Several findings show the potential applicability of microRNAs as biomarkers of malignancy and prognosis, and there are some data on lncRNA as well. In this review, we present a synopsis on the potential relevance of non-coding RNA molecules in adrenocortical pathogenesis and their applicability in diagnosis from tissue and blood.
包括微小RNA和长链非编码RNA（lncRNA）在内的非编码RNA分子已被认为与多种肿瘤的发病机制有关，大量数据也支持它们在诊断中的应用。尽管有了最新进展，但肾上腺皮质癌的发病机制仍然难以捉摸，也没有可靠的肾上腺皮质恶性肿瘤血源性标志物。一些研究结果表明微小RNA作为恶性肿瘤和预后生物标志物具有潜在的应用价值，关于lncRNA也有一些数据。在本综述中，我们概述了非编码RNA分子在肾上腺皮质发病机制中的潜在相关性及其在组织和血液诊断中的应用。
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