Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Department of Molecular Biosciences, The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden.
Br J Pharmacol. 2019 Jul;176(14):2416-2432. doi: 10.1111/bph.14631. Epub 2019 Apr 7.
Adrenoceptors play an important role in adipose tissue biology and physiology that includes regulating the synthesis and storage of triglycerides (lipogenesis), the breakdown of stored triglycerides (lipolysis), thermogenesis (heat production), glucose metabolism, and the secretion of adipocyte-derived hormones that can control whole-body energy homeostasis. These processes are regulated by the sympathetic nervous system through actions at different adrenoceptor subtypes expressed in adipose tissue depots. In this review, we have highlighted the role of adrenoceptor subtypes in white, brown, and brite adipocytes in both rodents and humans and have included detailed analysis of adrenoceptor expression in human adipose tissue and clonally derived adipocytes. We discuss important considerations when investigating adrenoceptor function in adipose tissue or adipocytes. LINKED ARTICLES: This article is part of a themed section on Adrenoceptors-New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc.
肾上腺素受体在脂肪组织生物学和生理学中发挥着重要作用，包括调节甘油三酯的合成和储存（脂肪生成）、储存的甘油三酯的分解（脂肪分解）、产热（热量产生）、葡萄糖代谢以及脂肪细胞衍生激素的分泌，这些激素可以控制全身能量平衡。这些过程受交感神经系统通过在脂肪组织库中表达的不同肾上腺素受体亚型的作用来调节。在这篇综述中，我们强调了肾上腺素受体亚型在啮齿动物和人类的白色、棕色和米色脂肪细胞中的作用，并对人类脂肪组织和克隆衍生脂肪细胞中的肾上腺素受体表达进行了详细分析。我们讨论了在研究脂肪组织或脂肪细胞中肾上腺素受体功能时需要考虑的重要因素。相关文章：本文是肾上腺素受体——旧角色的新角色专题的一部分。要查看本节中的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc.
