Szentirmai Éva, Kapás Levente
Elson S. Floyd College of Medicine, Department of Translational Medicine and Physiology, Washington State University, Spokane, WA, United States of America.
Sleep and Performance Research Center, Washington State University, Spokane, WA, United States of America.
Neurobiol Sleep Circadian Rhythms. 2025 Apr 24;18(Suppl):100122. doi: 10.1016/j.nbscr.2025.100122. eCollection 2025 May.
The regulation of sleep, while primarily attributed to the interplay between circadian and homeostatic processes, is significantly influenced by a multitude of additional factors that profoundly impact sleep quantity and quality. These factors encompass both external environmental stimuli, such as ambient temperature and somatosensory inputs, and internal physiological changes. The intricate relationship between metabolism and sleep has been a subject of extensive research, with particular attention given to the role of metabolic signals in sleep regulation. Among these, the brown adipose tissue (BAT) has emerged as a key player, studied from various perspectives including its physiological responses to sleep deprivation, its effects on sleep when activated, the consequences of impaired BAT thermogenesis on sleep patterns, and its metabolic activity across different sleep states. The cumulative evidence from these investigations suggests that BAT plays a crucial role in maintaining an optimal metabolic environment conducive to sleep, a function that becomes particularly significant in contexts of prior sleep loss, inflammatory conditions, and fluctuations in ambient temperature.
睡眠的调节虽然主要归因于昼夜节律和稳态过程之间的相互作用，但还受到许多其他因素的显著影响，这些因素会深刻影响睡眠的数量和质量。这些因素包括外部环境刺激，如环境温度和体感输入，以及内部生理变化。新陈代谢与睡眠之间的复杂关系一直是广泛研究的主题，尤其关注代谢信号在睡眠调节中的作用。其中，棕色脂肪组织（BAT）已成为关键角色，人们从多个角度对其进行了研究，包括其对睡眠剥夺的生理反应、激活时对睡眠的影响、BAT产热受损对睡眠模式的后果，以及其在不同睡眠状态下的代谢活动。这些研究的累积证据表明，BAT在维持有利于睡眠的最佳代谢环境中起着关键作用，这一功能在先前睡眠不足、炎症状态和环境温度波动的情况下尤为重要。
