Hanaue H, Kurosawa T, Kitano Y, Miyakawa S, Horie F, Nemoto A, Shikata J
Cancer. 1986 Feb 15;57(4):693-8. doi: 10.1002/1097-0142(19860215)57:4<693::aid-cncr2820570402>3.0.co;2-a.
The influence of fat emulsification of N1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) on lymphatic transport was studied in seven postoperative gastric cancer patients. The water-in-oil-type of emulsion of FT-207 (FT-w/o), the oil-in-water-type emulsion of FT-207 (FT-o/w) and an enteric-coated granule of FT-207 (FT-G) each in 1-g doses, calculated in terms of FT-207, were administered orally. Lymph from a thoracic duct fistula, prepared in advance, and from the blood of a peripheral vein was collected simultaneously along a time course after administration to measure the concentrations of FT-207 and 5-fluorouracil (5-FU). For FT-w/o, FT-207, and 5-FU, concentrations were significantly higher, both in the lymph and in the blood, than those for FT-G and FT-o/w. However, no significant differences in FT-207 and 5-FU concentrations were observed between FT-o/w and FT-G. It was concluded that FT-w/o can be useful as an adjuvant chemotherapeutic drug in the postoperative treatment of gastric cancer.
研究了N1-(2-四氢呋喃基)-5-氟尿嘧啶（FT-207）脂肪乳化对7例胃癌术后患者淋巴转运的影响。分别以1g剂量口服给予FT-207的油包水型乳剂（FT-w/o）、水包油型乳剂（FT-o/w）和FT-207肠溶颗粒（FT-G），剂量按FT-207计算。给药后，沿着时间进程同时收集预先制备的胸导管瘘管的淋巴液和外周静脉血，以测量FT-207和5-氟尿嘧啶（5-FU）的浓度。对于FT-w/o，其FT-207和5-FU在淋巴液和血液中的浓度均显著高于FT-G和FT-o/w。然而，FT-o/w和FT-G之间的FT-207和5-FU浓度未观察到显著差异。得出的结论是，FT-w/o可作为胃癌术后辅助化疗药物。
