Arima S, Futami K, Toriya H, Shimura H
Chikushi Hospital, School of Medicine, Fukuoka University, Japan.
Jpn J Surg. 1989 Mar;19(2):177-81. doi: 10.1007/BF02471582.
Forty-one patients with advanced gastric cancer underwent gastrectomy and the correlation between tissue uptake of the adjuvant drug and the prognosis were studied. The patients were preoperatively administered Tegafur (Futraful, Taiho Pharmaceutical Co. Ltd, Japan) and samples of tissue were obtained intraoperatively. 5-FU levels in the tumor and lymph nodes were measured by gas chromato-massfragmentography (GCMF). The patients in whom the 5-FU uptake by the tissues was measured and who were given over 60 g of Tegafur as postoperative adjuvant chemotherapy, were divided into two groups; namely, one group in whom the 5-FU uptake by the tumor tissue and lymph nodes was over 0.05 microgram/g and the other in whom the uptake was lower than 0.05 microgram/g. There were no significant differences in the background factors of either group. Each survival rate was calculated by the Kaplan-Meier method, and the generalized Wilcoxon method was used for statistical analysis. There was no statistically significant correlation between the 5-FU uptake by the tumor and the prognosis, however the 5-year survival rate in the group whose 5-FU uptake of the lymph nodes was over 0.05 microgram/g was statistically significant (p = 0.018).
41例晚期胃癌患者接受了胃切除术，并对辅助药物的组织摄取与预后之间的相关性进行了研究。患者术前给予替加氟（喃氟啶，日本大鹏药品工业株式会社），术中获取组织样本。采用气相色谱 - 质谱联用法（GCMF）测定肿瘤和淋巴结中的5 - 氟尿嘧啶（5 - FU）水平。对测量了组织5 - FU摄取量且术后辅助化疗给予超过60 g替加氟的患者分为两组；即肿瘤组织和淋巴结5 - FU摄取量超过0.05微克/克的一组，以及摄取量低于0.05微克/克的另一组。两组的背景因素无显著差异。各生存率采用Kaplan - Meier法计算，采用广义Wilcoxon法进行统计分析。肿瘤5 - FU摄取与预后之间无统计学显著相关性，然而淋巴结5 - FU摄取量超过0.05微克/克的组的5年生存率具有统计学显著性（p = 0.018）。
