微栓子与血浆D-二聚体在评估心房颤动患者华法林抗凝治疗疗效中的作用

Roles of Microembolus and Plasma D-dimer in Evaluating the Warfarin Anticoagulant Therapy Efficacies for Patients with Atrial Fibrillation.

作者信息

Xu Yun, Wang Bing, Jiang Li-Jiao, Lu Xiao-Ping, Zhao Xiao-Ying, Wang Fang

机构信息

Department of Cardiology, Wuzhong People's Hospital, Suzhou.

出版信息

Heart Surg Forum. 2019 Jan 28;22(1):E015-E018. doi: 10.1532/hsf.2197.

DOI:10.1532/hsf.2197

PMID:30802191

Abstract

BACKGROUND

To investigate the roles of microembolus and plasma D-dimer in evaluating the warfarin anticoagulant therapy efficacies for patients with atrial fibrillation (AF).

METHODS

Fifty-six AF patients were treated with aspirin antiplatelet therapy (Group ASP) and forty AF patients were treated with warfarin anticoagulant therapy (Group WAR). The microemboli and plasma D-dimer in these two groups were monitored and compared before and after treatment.

RESULTS

Group ASP had 21 and 17 cases with positive microemboli before and after treatment, respectively, and there was no significant difference in the detection rate of microemboli before and after treatment; Group WAR had 14 and 5 cases with positive microemboli before and after treatment, respectively, and the detection rate of microemboli was significantly reduced after treatment. The levels of plasma D-dimer in the two groups were significantly reduced after treatment (327±73 µg/L vs 235±61 µg/L and 313±81 µg/L vs 170±67 µg/L, respectively, P<0.05), among which the reduction level in Group WAR was more significant.

CONCLUSIONS

Microemboli and D-dimer can be used as the indicators for evaluating the embolism risk and therapeutic efficacies in AF patients.

摘要

背景

探讨微栓子及血浆D - 二聚体在评估心房颤动（AF）患者华法林抗凝治疗疗效中的作用。

方法

56例AF患者接受阿司匹林抗血小板治疗（ASP组），40例AF患者接受华法林抗凝治疗（WAR组）。监测并比较两组治疗前后的微栓子及血浆D - 二聚体情况。

结果

ASP组治疗前、后微栓子阳性分别为21例和17例，治疗前后微栓子检出率无显著差异；WAR组治疗前、后微栓子阳性分别为14例和5例，治疗后微栓子检出率显著降低。两组治疗后血浆D - 二聚体水平均显著降低（分别为327±73μg/L对235±61μg/L和313±81μg/L对170±67μg/L，P<0.05），其中WAR组降低更为显著。