Adriamycin and DT-diaphorase.
作者信息
Wallin R
出版信息
Cancer Lett. 1986 Jan;30(1):97-101. doi: 10.1016/0304-3835(86)90138-2.
PMID:3080227
Abstract
It has been suggested that DT-diaphorase (EC 1.6.99.2) can oppose the cytotoxic effect of the antineoplastic drug adriamycin. In this study, adriamycin was tested as a substrate for purified DT-diaphorase from rat liver. Purified DT-diaphorase was unable to use adriamycin as substrate. Also, the drug did not have any significant inhibitory effect on the enzyme.
摘要
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