Gojobori M, Mashiba H, Matsunaga K, Jimi S
Gan. 1978 Apr;69(2):201-6.
Peripheral blood lymphocytes from healthy donors, cancer patients, and noncancer patients were cultured with or without phytohemagglutinin (PHA) for 3 days, supernatant containing lymphotoxin (LT) was added to L cells, and LT activities were examined. LT release by PHA-stimulated lymphocytes from patients with uterine cervical cancer in stages 0 and I decreased and the degree of the decrease was much more marked in stage IV. However, LT activities released spontaneously without PHA were higher in patients with uterine myoma, patients with uterine cervical cancer in stages II to IV, patients with pulmonary tuberculosis, and patients with gastro-intestinal cancer. Relation of LT release and blastogenesis following stimulation with PHA was also examined. Correlation was observed in only 14 out of 43 patients with uterine cervical cancer (32.6%). The role of LT in cancer patients was discussed.
将健康供体、癌症患者和非癌症患者的外周血淋巴细胞在有或无植物血凝素（PHA）的情况下培养3天，将含有淋巴毒素（LT）的上清液加入L细胞中，并检测LT活性。0期和I期子宫颈癌患者经PHA刺激的淋巴细胞释放的LT减少，而IV期的减少程度更为明显。然而，子宫肌瘤患者、II至IV期子宫颈癌患者、肺结核患者和胃肠道癌患者在无PHA刺激时自发释放的LT活性较高。还研究了PHA刺激后LT释放与细胞增殖的关系。在43例子宫颈癌患者中，只有14例（32.6%）观察到相关性。文中讨论了LT在癌症患者中的作用。
