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1
Ontogeny of murine-B-lymphocytes. Avidity of antigen binding cells in neonatal and adult mice.小鼠B淋巴细胞的个体发生。新生小鼠和成年小鼠中抗原结合细胞的亲和力。
Immunology. 1978 Jun;34(6):1089-96.
2
Ontogeny of B-lymphocyte function. IX. Difference in the time of maturation of the capacity of B lymphocytes from foetal and neonatal mice to produce a heterogeneous antibody response to thymic-dependent and thymic-independent antigens.B淋巴细胞功能的个体发生。IX. 胎鼠和新生鼠B淋巴细胞对胸腺依赖性和胸腺非依赖性抗原产生异质性抗体反应能力的成熟时间差异。
Immunology. 1979 Apr;36(4):891-907.
3
Clonal analysis of the primary and secondary B cell responses of neonatal, adult, and xid mice to (T,G)-A--L.对新生小鼠、成年小鼠和xid小鼠针对（T，G）-A--L的初级和次级B细胞反应进行克隆分析。
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4
Assessing B cell diversification by antigen receptor and precursor cell analysis.通过抗原受体和前体细胞分析评估B细胞多样性。
Ann Immunol (Paris). 1976 Jun-Jul;127(3-4):489-502.
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Age-dependent changes in the relative affinity of anti-dinitrophenyl antibodies in mice.小鼠中抗二硝基苯基抗体相对亲和力的年龄依赖性变化。
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A reappraisal of "T-independent" antigens. II. Studies on single, hapten-specific B cells from neonatal CBA/H or CBA/N mice fail to support classification into TI-1 and TI-2 categories.对“非T细胞依赖性”抗原的重新评估。II. 对新生CBA/H或CBA/N小鼠中单个半抗原特异性B细胞的研究未能支持将其分类为TI-1和TI-2类别。
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8
Neonatal murine B lymphocytes respond to polysaccharide antigens in the presence of IL-1 and IL-6.新生小鼠B淋巴细胞在白细胞介素-1和白细胞介素-6存在的情况下对多糖抗原产生反应。
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The acquisition of b-cell competence and diversity.B细胞能力与多样性的获得。
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The influence of avidity on signaling murine B lymphocytes with monoclonal anti-IgM antibodies. Effects of B cell proliferation versus growth inhibition (tolerance) of an immature B cell lymphoma.亲和力对用单克隆抗IgM抗体刺激小鼠B淋巴细胞信号传导的影响。未成熟B细胞淋巴瘤的B细胞增殖与生长抑制（耐受）的作用。
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本文引用的文献

1
General method for the detection of cells producing antibodies against haptens and proteins.检测产生针对半抗原和蛋白质的抗体的细胞的一般方法。
Nature. 1970 Jul 4;227(5253):68-9. doi: 10.1038/227068a0.
2
Presence of antigen-binding cells for five diverse antigens at the onset of lymphoid development: lack of evidence for somatic diversification during ontogeny.在淋巴样发育开始时存在针对五种不同抗原的抗原结合细胞：个体发育过程中缺乏体细胞多样化的证据。
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Characterization of splenic lymphoid cells in fetal and newborn mice.胎儿和新生小鼠脾脏淋巴细胞的特征分析
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Specific fractionation of immune cell populations.免疫细胞群体的特异性分级分离。
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Somatic translocation of antibody genes.抗体基因的体细胞易位。
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6
The generation of antibody diversity: its dependence on antigenic stimulation.抗体多样性的产生：其对抗原刺激的依赖性。
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Ontogeny of B-lymphocyte function. I. Restricted heterogeneity of the antibody response of B lymphocytes from neonatal and fetal mice.B淋巴细胞功能的个体发生。I. 新生和胎儿小鼠B淋巴细胞抗体反应的有限异质性。
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Selection under a somatic model.体细胞模型下的选择
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9
Frequency and avidity of specific antigen-binding cells in developing mice.发育中小鼠体内特异性抗原结合细胞的频率和亲和力
J Exp Med. 1975 Nov 1;142(5):1078-91. doi: 10.1084/jem.142.5.1078.
10
Age-dependent changes in the relative affinity of anti-dinitrophenyl antibodies in mice.小鼠中抗二硝基苯基抗体相对亲和力的年龄依赖性变化。
Immunology. 1975 Sep;29(3):477-86.

小鼠B淋巴细胞的个体发生。新生小鼠和成年小鼠中抗原结合细胞的亲和力。

Ontogeny of murine-B-lymphocytes. Avidity of antigen binding cells in neonatal and adult mice.

作者信息

Marshall-Clarke S, Playfair J H

出版信息

Immunology. 1978 Jun;34(6):1089-96.

PMID:308037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457415/
Abstract

The heterogeneity of avidity of DNP-binding (rosetting) cells has been studied in mice of various ages, in an attempt to learn more about the development of antibody diversity. The results indicate that during the neonatal period murine B cells show a limited heterogeneity of avidity with no "high" avidity ABC being detectable. This implies that the full repertoire of anti-DNP antibodies is only gradually acquired during ontogeny. The results are interpreted as favouring the hypothesis that somatic events are important in the generation of antibody diversity.

摘要

为了更多地了解抗体多样性的发育过程，对不同年龄小鼠中DNP结合（玫瑰花结形成）细胞的亲和力异质性进行了研究。结果表明，在新生期，小鼠B细胞显示出有限的亲和力异质性，未检测到“高”亲和力ABC。这意味着抗DNP抗体的完整库仅在个体发育过程中逐渐获得。这些结果被解释为支持体细胞事件在抗体多样性产生中起重要作用的假说。