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小鼠B淋巴细胞的个体发生。新生小鼠和成年小鼠中抗原结合细胞的亲和力。

Ontogeny of murine-B-lymphocytes. Avidity of antigen binding cells in neonatal and adult mice.

作者信息

Marshall-Clarke S, Playfair J H

出版信息

Immunology. 1978 Jun;34(6):1089-96.

PMID:308037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457415/
Abstract

The heterogeneity of avidity of DNP-binding (rosetting) cells has been studied in mice of various ages, in an attempt to learn more about the development of antibody diversity. The results indicate that during the neonatal period murine B cells show a limited heterogeneity of avidity with no "high" avidity ABC being detectable. This implies that the full repertoire of anti-DNP antibodies is only gradually acquired during ontogeny. The results are interpreted as favouring the hypothesis that somatic events are important in the generation of antibody diversity.

摘要

为了更多地了解抗体多样性的发育过程，对不同年龄小鼠中DNP结合（玫瑰花结形成）细胞的亲和力异质性进行了研究。结果表明，在新生期，小鼠B细胞显示出有限的亲和力异质性，未检测到“高”亲和力ABC。这意味着抗DNP抗体的完整库仅在个体发育过程中逐渐获得。这些结果被解释为支持体细胞事件在抗体多样性产生中起重要作用的假说。

相似文献

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Ontogeny of murine-B-lymphocytes. Avidity of antigen binding cells in neonatal and adult mice.小鼠B淋巴细胞的个体发生。新生小鼠和成年小鼠中抗原结合细胞的亲和力。
Immunology. 1978 Jun;34(6):1089-96.
2
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本文引用的文献

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Somatic translocation of antibody genes.抗体基因的体细胞易位。
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Ontogeny of B-lymphocyte function. I. Restricted heterogeneity of the antibody response of B lymphocytes from neonatal and fetal mice.B淋巴细胞功能的个体发生。I. 新生和胎儿小鼠B淋巴细胞抗体反应的有限异质性。
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Selection under a somatic model.体细胞模型下的选择
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Frequency and avidity of specific antigen-binding cells in developing mice.发育中小鼠体内特异性抗原结合细胞的频率和亲和力
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Age-dependent changes in the relative affinity of anti-dinitrophenyl antibodies in mice.小鼠中抗二硝基苯基抗体相对亲和力的年龄依赖性变化。
Immunology. 1975 Sep;29(3):477-86.

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