Marshall-Clarke S, Playfair J H
Immunology. 1978 Jun;34(6):1089-96.
The heterogeneity of avidity of DNP-binding (rosetting) cells has been studied in mice of various ages, in an attempt to learn more about the development of antibody diversity. The results indicate that during the neonatal period murine B cells show a limited heterogeneity of avidity with no "high" avidity ABC being detectable. This implies that the full repertoire of anti-DNP antibodies is only gradually acquired during ontogeny. The results are interpreted as favouring the hypothesis that somatic events are important in the generation of antibody diversity.
为了更多地了解抗体多样性的发育过程,对不同年龄小鼠中DNP结合(玫瑰花结形成)细胞的亲和力异质性进行了研究。结果表明,在新生期,小鼠B细胞显示出有限的亲和力异质性,未检测到“高”亲和力ABC。这意味着抗DNP抗体的完整库仅在个体发育过程中逐渐获得。这些结果被解释为支持体细胞事件在抗体多样性产生中起重要作用的假说。