从前列腺健康到膀胱过度活动症：开发国际前列腺症状评分（IPSS）与膀胱过度活动症问卷简表（OAB-V8）之间的对照转换表
From Prostate Health to Overactive Bladder: Developing a Crosswalk for the IPSS to OAB-V8.
作者信息
Trafford Crump Robert, Sehgal Anika, Wright Ian, Carlson Kevin, Baverstock Richard
机构信息
Department of Surgery, University of Calgary, Calgary, Alberta, Canada.
VESIA [Alberta Bladder Centre], Calgary, Alberta, Canada.
出版信息
Urology. 2019 Mar;125:73-78. doi: 10.1016/j.urology.2018.10.035. Epub 2018 Oct 26.
OBJECTIVES
To develop a statistical model to facilitate the comparison of 2 common patient-reported outcome (PRO) instruments in male lower urinary tract symptoms.
METHODS
Two PROs used by urologists are the International Prostate Symptoms Severity (IPSS) and the Overactive Bladder-Validated 8 questions (OAB-V8). The former measures symptoms related to prostate cancer, the latter measures the severity of symptoms related to OAB. Ordinary least squares regression was used to develop 3 models for translating responses to the IPSS into OAB-V8 scores. The root mean square error was used to compare the models.
RESULTS
The sample consisted of 493 participants, ranging from 18 to 93 years of age. The recommended model included the individual responses to the IPSS' items and participants' age. Due to the low root mean square error (0.7606), indicating low variation and high precision, we can explain about 63% (R2 = 0.6260) relationship between IPSS and OAB-v8.
CONCLUSION
This study successfully modeled global OAB-V8 scores from IPSS responses. This model performed comparably well to others developed using similar methods.
目的
建立一个统计模型，以促进对男性下尿路症状中两种常见的患者报告结局（PRO）工具进行比较。
方法
泌尿科医生使用的两种PRO工具分别是国际前列腺症状严重程度（IPSS）和膀胱过度活动症验证的8个问题（OAB-V8）。前者测量与前列腺癌相关的症状，后者测量与膀胱过度活动症相关症状的严重程度。采用普通最小二乘法回归建立3个将IPSS的反应转化为OAB-V8评分的模型。用均方根误差比较这些模型。
结果
样本包括493名参与者，年龄在18至93岁之间。推荐的模型包括对IPSS项目的个体反应和参与者的年龄。由于均方根误差较低（0.7606），表明变异低且精度高，我们可以解释IPSS和OAB-V8之间约63%（R2 = 0.6260）的关系。
结论
本研究成功地根据IPSS反应建立了OAB-V8总体评分模型。该模型的表现与使用类似方法开发的其他模型相当。
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