Centre for Health Services and Policy Research, University of British Columbia, Vancouver, British Columbia, Canada.
Vesia [Alberta Bladder Centre], Calgary, Alberta, Canada.
Neurourol Urodyn. 2018 Mar;37(3):1095-1100. doi: 10.1002/nau.23420. Epub 2017 Oct 4.
The OAB-v8 is a patient-reported outcome questionnaire used to screen for overactive bladder and measure symptom bother. This study uses modern validation methods to assess the item and test characteristics of the OAB-v8, and determine whether it should be scored differently for men and women.
A secondary analysis of data from patients with lower urinary tract symptoms prospectively recruited from a urology clinic in Calgary, Canada. Item-response theory (IRT) was used to evaluate the dimensionality, reliability, and validity of the OAB-v8, and differential functioning analysis (DIF) was used to determine whether the OAB-v8 should be scored differently for men and women.
A total of 1128 patients were included for analysis, of which 28% were female. Mean OAB-v8 scores indicated meaningful levels of symptom bother, and women scored 2 points higher, on average, than men (P = 0.005). Reliability was high (Cronbach's alpha = 0.901) for a wide range of patients (between -2 and 2.5 standard deviations of the mean). Samejima's graded response model best fit the data, and the scale demonstrated essential unidimensionality. Items #5 and #6 were excessively correlated. There was no evidence of differential functioning.
OAB-v8 demonstrated high reliability and would be appropriate for a wide range of patients. Items #5 and #6 may need to be re-worded. The OAB-v8 should not be scored differently for men and women, although women do appear to experience higher average levels of symptom bother from OAB than men.
OAB-v8 是一种患者报告的结局问卷，用于筛查膀胱过度活动症并测量症状困扰。本研究使用现代验证方法评估 OAB-v8 的项目和测试特征，并确定其是否应针对男性和女性进行不同的评分。
这是对来自加拿大卡尔加里泌尿科诊所的下尿路症状患者进行前瞻性招募的数据进行的二次分析。使用项目反应理论（IRT）评估 OAB-v8 的维度、可靠性和有效性，并使用差异功能分析（DIF）确定 OAB-v8 是否应针对男性和女性进行不同的评分。
共有 1128 名患者纳入分析，其中 28%为女性。OAB-v8 的平均得分表明症状困扰程度具有一定意义，女性的平均得分比男性高 2 分（P=0.005）。对于广泛的患者群体（平均标准差的-2 到 2.5 之间），可靠性很高（Cronbach's alpha=0.901）。Samejima 的分级反应模型最适合数据，并且该量表表现出基本的单维度性。第 5 项和第 6 项的相关性过高。没有证据表明存在功能差异。
OAB-v8 具有较高的可靠性，适用于广泛的患者群体。第 5 项和第 6 项可能需要重新措辞。OAB-v8 不应针对男性和女性进行不同的评分，尽管女性似乎比男性经历更高的平均 OAB 症状困扰程度。
