Yao Henry Han-I, Crump Robert Trafford, Charbonneau Camille, Khan Asher, Barton Carly, Brotherhood Hilary, Jiang Jing, Carlson Kevin V, Baverstock Richard J
Vesia (Alberta Bladder Centre), Calgary, Alberta, Canada.
Department of Surgery, University of Calgary, Calgary, Alberta, Canada.
Transl Androl Urol. 2020 Oct;9(5):2046-2053. doi: 10.21037/tau-20-689.
Research on prostate cancer survivorship patients has largely been on oncological outcome, incontinence and erectile dysfunction, with less data on the relationship between prostate cancer, bladder function and mental health. This study aims to elucidate the prevalence of lower urinary tract symptoms (LUTS), overactive bladder (OAB), sexual dysfunction, depression and anxiety in Canadian men with newly diagnosed localised prostate cancer.
This is a single-centre prospective cross-sectional study of men with newly diagnosed localized prostate cancer recruited from June 2017 to July 2018. The patient-reported outcomes (PRO) instruments used in this study included the international prostate symptoms score (IPSS), OAB-V8, EQ-5D™, and the Expanded Prostate Cancer Index Composite short form (EPIC-26). Clinico-pathological data were extracted from medical records. The prevalence of LUTS, OAB, sexual dysfunction, depression and anxiety were determined from the PROs.
A total of 83 patients were included in this study. The median age was 63. Based on IPSS scores, 55.3% of men had mild LUTS, 36.8% had moderate LUTS and 7.9% had severe LUTS. Based on OAB-V8 scores, 55.8% of men had a score of 8 or higher, suggestive of OAB. Only 55.8% of men reported erections adequate for intercourse. 23.1% of men reported to have a moderate to big problem with depression, and 28.8% of men reported to have a degree of anxiety or depression.
OAB is a significant problem in men with newly diagnosed localized prostate cancer, with a prevalence of 55.8% based on this study. Baseline sexual dysfunction, anxiety and depression are also prevalent in this population.
前列腺癌存活患者的研究主要集中在肿瘤学结局、尿失禁和勃起功能障碍方面，而关于前列腺癌、膀胱功能与心理健康之间关系的数据较少。本研究旨在阐明加拿大新诊断为局限性前列腺癌的男性中，下尿路症状（LUTS）、膀胱过度活动症（OAB）、性功能障碍、抑郁和焦虑的患病率。
这是一项单中心前瞻性横断面研究，研究对象为2017年6月至2018年7月招募的新诊断为局限性前列腺癌的男性。本研究中使用的患者报告结局（PRO）工具包括国际前列腺症状评分（IPSS）、OAB-V8、EQ-5D™和扩展前列腺癌指数综合简表（EPIC-26）。临床病理数据从医疗记录中提取。根据PROs确定LUTS、OAB、性功能障碍、抑郁和焦虑的患病率。
本研究共纳入83例患者。中位年龄为63岁。根据IPSS评分，55.3%的男性有轻度LUTS，36.8%有中度LUTS，7.9%有重度LUTS。根据OAB-V8评分，55.8%的男性得分8分或更高，提示存在OAB。只有55.8%的男性报告勃起功能足以进行性交。23.1%的男性报告有中度至重度抑郁问题，28.8%的男性报告有一定程度的焦虑或抑郁。
OAB是新诊断为局限性前列腺癌的男性中的一个重要问题，根据本研究，其患病率为55.8%。基线性功能障碍、焦虑和抑郁在该人群中也很普遍。
