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恐惧消退的多巴胺基础。

A Dopaminergic Basis for Fear Extinction.

机构信息

Deutsches Resilienz Zentrum (DRZ), Johannes Gutenberg University Medical Center, Mainz, Germany; Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center, Mainz, Germany.

Department of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands.

出版信息

Trends Cogn Sci. 2019 Apr;23(4):274-277. doi: 10.1016/j.tics.2019.01.013. Epub 2019 Feb 22.

DOI:10.1016/j.tics.2019.01.013
PMID:30803871
Abstract

It is a joyous relief when an event we dread fails to materialize. In fear extinction, the appetitive nature of an omitted aversive event is not a mere epiphenomenon but drives the reduction of fear responses and the formation of long-term extinction memories. Dopamine emerges as key neurobiological mediator of these related processes.

摘要

当我们恐惧的事件没有发生时，我们会感到一种愉悦的解脱。在恐惧消退中，被省略的厌恶事件的欲望性质不仅仅是一种副现象，而是驱动了恐惧反应的减少和长期消退记忆的形成。多巴胺作为这些相关过程的关键神经生物学介质出现。

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[2]
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[3]
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[6]
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[2]
Dopamine induces fear extinction by activating the reward-responding amygdala neurons.

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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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