食管癌手术围手术期应用类固醇治疗及术后加强康复护理后，术后C反应蛋白水平是一个预后指标。
Postoperative Level of C-Reactive Protein Is a Prognosticator After Esophageal Cancer Surgery With Perioperative Steroid Therapy and Enhanced Recovery After Surgery Care.
作者信息
Kano Kazuki, Aoyama Toru, Maezawa Yukio, Hayashi Tsutomu, Yamada Takanobu, Tamagawa Hiroshi, Sato Tsutomu, Cho Haruhiko, Yoshikawa Takaki, Rino Yasushi, Masuda Munetaka, Oshima Takashi, Ogata Takashi
机构信息
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Kanagawa, Japan.
Department of Surgery, Yokohama City University, Kanagawa, Japan.
出版信息
In Vivo. 2019 Mar-Apr;33(2):587-594. doi: 10.21873/invivo.11515.
Abstract
BACKGROUND
This study investigated the impact of postoperative C-reactive protein (CRP) level on survival in patients with esophageal cancer who received perioperative steroid therapy and enhanced recovery after surgery (ERAS) care.
PATIENTS AND METHODS
Overall, 115 patients were retrospectively reviewed. The patients were classified into those with a high CRP level (≥4.0 mg/dl) on postoperative day 4 and those with low CRP level (<4.0 mg/dl). The risk factors for overall survival (OS) and recurrence-free survival (RFS) were identified.
RESULTS
The OS and RFS rates at 5 years after surgery were significantly low in patients with high CRP level on postoperative day 4. The multivariate analysis demonstrated that high CRP level on postoperative day 4 was a significant independent risk factor for OS and RFS.
CONCLUSION
The present results suggest that the postoperative CRP level can be a prognosticator in patients with esophageal cancer who have received perioperative steroid therapy and ERAS care.
摘要
背景
本研究调查了围手术期接受类固醇治疗及术后加速康复（ERAS）护理的食管癌患者术后C反应蛋白（CRP）水平对生存的影响。
患者与方法
共对115例患者进行回顾性分析。将患者分为术后第4天CRP水平高（≥4.0mg/dl）组和CRP水平低（<4.0mg/dl）组。确定总生存期（OS）和无复发生存期（RFS）的危险因素。
结果
术后第4天CRP水平高的患者术后5年的OS率和RFS率显著较低。多因素分析表明，术后第4天CRP水平高是OS和RFS的显著独立危险因素。
结论
目前结果提示，术后CRP水平可作为接受围手术期类固醇治疗及ERAS护理的食管癌患者的预后指标。
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