在生殖细胞肿瘤治疗中，第1天和第5天使用帕洛诺司琼，第1 - 5天每日使用格拉司琼。
Palonosetron on Days 1 and 5 Granisetron Daily (Days 1-5) in Germ Cell Tumour Therapy.
作者信息
Shimura Yusuke, Izumi Kouji, Itai Shingo, Iwamoto Hiroaki, Yaegashi Hiroshi, Suga Yukio, Shimada Tsutomu, Mizokami Atsushi, Sai Yoshimichi
机构信息
Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan.
Department of Clinical Drug Informatics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical & Health Sciences, Kanazawa University, Kanazawa, Japan.
出版信息
In Vivo. 2019 Mar-Apr;33(2):643-647. doi: 10.21873/invivo.11522.
BACKGROUND/AIM: The control of chemotherapy-induced nausea and vomiting during bleomycin, etoposide, and cisplatin (BEP) treatment is important for maintaining treatment intensity. The effects of palonosetron and granisetron were compared in BEP chemotherapy.
PATIENTS AND METHODS
The administration of palonosetron on days 1 and 5 (Pal method) and granisetron daily (days 1-5, Gra method) were compared in terms of their efficacy and cost-effectiveness.
RESULTS
Additional rescue antiemetic agents were used in 15 of 32 and 30 of 30 cycles in the Pal and Gra method groups, respectively (p<0.05). The complete response rate, defined as no vomiting and no rescue agent usage, in each cycle, was 50% and 0% in the Pal and Gra method groups, respectively (p<0.05). The average cost of antiemetic agents in a cycle was 50,759 and 54,555 yen in the Pal and Gra method groups, respectively (p<0.05).
CONCLUSION
The Pal method may be the standard method in BEP.
背景/目的：在博来霉素、依托泊苷和顺铂（BEP）治疗期间，控制化疗引起的恶心和呕吐对于维持治疗强度至关重要。比较了帕洛诺司琼和格拉司琼在BEP化疗中的效果。
患者和方法
比较了第1天和第5天给予帕洛诺司琼（帕洛诺司琼法）与每天给予格拉司琼（第1 - 5天，格拉司琼法）的疗效和成本效益。
结果
帕洛诺司琼法组和格拉司琼法组分别在32个周期中的15个周期和30个周期中使用了额外的解救性止吐药（p<0.05）。每个周期中，定义为无呕吐且未使用解救药的完全缓解率在帕洛诺司琼法组和格拉司琼法组中分别为50%和0%（p<0.05）。帕洛诺司琼法组和格拉司琼法组一个周期中使用止吐药的平均费用分别为50,759日元和54,555日元（p<0.05）。
结论
帕洛诺司琼法可能是BEP治疗中的标准方法。
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