高危II期结肠癌患者错配修复状态的临床意义
Clinical Implications of Mismatch Repair Status in Patients With High-risk Stage II Colon Cancer.
作者信息
Baek Dong Won, Kang Byung Woog, Lee Soo Jung, Kim Hye Jin, Park Su Yeon, Park Jun Seok, Choi Gyu Seog, Baek Jin Ho, Kim Jong Gwang
机构信息
Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, Republic of Korea.
Department of Surgery, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
出版信息
In Vivo. 2019 Mar-Apr;33(2):649-657. doi: 10.21873/invivo.11523.
BACKGROUND/AIM: This study evaluated the clinical significance of the mismatch repair (MMR) status and prognostic factors in patients with high-risk stage II colon cancer (CC).
MATERIALS AND METHODS
This was a retrospective analysis of 237 patients diagnosed with high-risk stage II CC who had test results for MMR status.
RESULTS
Among the 237 patients, 76 (32.1%) were identified as having a microsatellite instability-high (MSI-H) status. No significant differences were identified in disease-free or overall survival according to the MMR status. Moreover, no association was found between the use of adjuvant chemotherapy and survival outcomes of the MSI-H group. In a multivariate survival analysis, the primary tumor location (right-sided versus left-sided, hazard ratio(HR)=0.172, p=0.003) and T-stage (HR=4.764, p=0.005) were identified as independent prognostic factors for disease-free survival.
CONCLUSION
The present study found that the MMR status was neither prognostic nor predictive in patients with high-risk stage II CC.
背景/目的：本研究评估了错配修复（MMR）状态及预后因素在高危II期结肠癌（CC）患者中的临床意义。
材料与方法
这是一项对237例诊断为高危II期CC且有MMR状态检测结果的患者进行的回顾性分析。
结果
在237例患者中，76例（32.1%）被确定为微卫星高度不稳定（MSI-H）状态。根据MMR状态，在无病生存期或总生存期方面未发现显著差异。此外，在MSI-H组中，辅助化疗的使用与生存结果之间未发现关联。在多因素生存分析中，原发肿瘤位置（右侧与左侧，风险比[HR]=0.172，p=0.003）和T分期（HR=4.764，p=0.005）被确定为无病生存期的独立预后因素。
结论
本研究发现，MMR状态在高危II期CC患者中既不是预后因素也不是预测因素。
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