低分化结直肠癌：微卫星不稳定性与临床病理特征和生存的相关性。
Poorly differentiated colorectal cancers: correlation of microsatellite instability with clinicopathologic features and survival.
机构信息
Department of Surgery, University of Ulsan College of Medicine, 86, Asanbyeongwon-gil, Songpa-gu, Seoul 138-736, Korea.
出版信息
Am J Clin Pathol. 2013 Sep;140(3):341-7. doi: 10.1309/AJCP8P2DYNKGRBVI.
OBJECTIVES
To evaluate the association of microsatellite instability (MSI) with clinicopathologic features and oncologic outcomes in patients with poorly differentiated colorectal cancer (PD).
METHODS
Study patients were divided into well-differentiated colorectal cancer (WD) and PD, which were compared according to histologic differentiation and MSI status.
RESULTS
Among 1,941 patients, PD was more frequent among microsatellite-unstable tumors (23.6%) than among microsatellite-stable (MSS) tumors (4.2%, P < .001). Patients with PD had worse 4-year overall survival rates than patients with WD (78.6% vs 88.2%, P = 0.010). Compared with MSS-PD tumors, MSI-PD tumors were characterized by right-colon predilection, larger size, and infrequent lymph node metastasis (P < .001 to P = .007).
CONCLUSIONS
The clinicopathologic characteristics of PD were closely associated with those of MSI. The outcomes of MSI-PD tumors were better than those of MSS-PD tumors, but this finding did not reach statistical significance.
目的
评估微卫星不稳定性（MSI）与分化不良型结直肠癌（PD）患者的临床病理特征和肿瘤学结局之间的关联。
方法
将研究患者分为分化良好型结直肠癌（WD）和 PD，根据组织学分化和 MSI 状态对其进行比较。
结果
在 1941 例患者中，MSI 不稳定肿瘤（23.6%）比 MSI 稳定（MSS）肿瘤（4.2%）更常见于 PD（P<0.001）。与 WD 患者相比，PD 患者的 4 年总生存率更差（78.6%比 88.2%，P=0.010）。与 MSS-PD 肿瘤相比，MSI-PD 肿瘤具有右结肠偏好、更大的肿瘤大小和较少发生淋巴结转移的特征（P<0.001 至 P=0.007）。
结论
PD 的临床病理特征与 MSI 密切相关。MSI-PD 肿瘤的结局优于 MSS-PD 肿瘤，但这一发现未达到统计学意义。
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