Saha Sonali, Dhinsa Gurpreet, Ghoshal Ujjala, Afzal Hussain Amrin Nayani Fatima, Nag Soumyabrata, Garg Aarti
Department of Pedodontics and Preventive Dentistry, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.
Department of Periodontology, Career Post Graduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India.
J Indian Soc Pedod Prev Dent. 2019 Jan-Mar;37(1):39-45. doi: 10.4103/JISPPD.JISPPD_66_18.
Microbes are considered as the primary etiological agents in endodontic diseases. Ways of reducing these agents are root canal debridement and antibacterial filling materials. One of the factors in determining the success of endodontic treatment previously was sealing root canals with materials possessing potent bactericidal effect. Due to cytotoxic reactions of sealers and their inability to eliminate bacteria completely from dentinal tubules, trend to use natural plants extracts have been introduced.
To compare antimicrobial activity of endodontic sealers added to herbal extracts.
Three sealers mixed with three herbal extracts were evaluated against seven strains of bacteria at various time intervals using Agar Diffusion Test. The mean zones of inhibition were measured.
All statistical analysis was performed using the SPSS 15 statistical software version, Chicago. Intergroup comparison was evaluated using Kruskal Walls test along with Mann Whitney U test. The Intragroup comparison was evaluatd using Friedman test along with Wilcoxon test.
Statistically significant zones of bacterial growth inhibition were observed largest with Zinc Oxide Eugenol based sealer when mixed with Glycyrrhiza glabra (Licorice) followed in descending order by zinc oxide eugenol based sealer mixed with Tinospora cordifolia (Guduchi) and Mimusops elengi (Bakul) respectively.
Zinc Oxide Eugenol based sealer with herbal extracts produced largest inhibitory zones followed in descending order by Resin based sealer and Calcium hydroxide along with three herbal extracts respectively.
微生物被认为是牙髓病的主要病因。减少这些病原体的方法是根管清创和使用抗菌填充材料。以前，决定牙髓治疗成功的因素之一是用具有强大杀菌作用的材料密封根管。由于封闭剂的细胞毒性反应以及它们无法从牙本质小管中完全清除细菌，因此引入了使用天然植物提取物的趋势。
比较添加草药提取物的牙髓封闭剂的抗菌活性。
使用琼脂扩散试验，在不同时间间隔对三种与三种草药提取物混合的封闭剂针对七种细菌菌株进行评估。测量平均抑菌圈。
所有统计分析均使用芝加哥SPSS 15统计软件版本进行。组间比较使用Kruskal Walls检验和Mann Whitney U检验进行评估。组内比较使用Friedman检验和Wilcoxon检验进行评估。
当氧化锌丁香酚基封闭剂与光果甘草（甘草）混合时，观察到具有统计学意义的最大细菌生长抑制圈，其次按降序排列的是分别与心叶锡生藤（古杜奇）和马缨丹（巴库尔）混合的氧化锌丁香酚基封闭剂。
添加草药提取物的氧化锌丁香酚基封闭剂产生的抑菌圈最大，其次按降序排列的是树脂基封闭剂和氢氧化钙分别与三种草药提取物混合后的情况。
