Dudás Csaba, Bardocz-Veres Zsuzsanna, Gyulai Anita Iulia, Pop Silvia Izabella, Székely Melinda, Kerekes-Máthé Bernadette, Kovács Mónika
Faculty of Dentistry, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 Târgu Mureș, Romania.
Department of Oral Rehabilitation and Occlusology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 Târgu Mureș, Romania.
Dent J (Basel). 2024 Dec 30;13(1):17. doi: 10.3390/dj13010017.
: Microorganisms are the leading cause of infections in the root canal system, contributing to the failure of endodontic treatments. This in vitro study aimed to compare the antimicrobial effects of four different endodontic sealers: Endomethasone N (Septodont, Saint Maur-des-Fossés, France), Sealapex (Kerr Corporation, Orange, CA, USA), AH Plus Jet (Dentsply DeTrey GmbH, Konstanz, Germany), and MTA Fillapex (Angelus, Londrina, Brazil). : The sealers were tested against common oral pathogens, including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Candida albicans, and Streptococcus mutans, using the agar diffusion method. Inhibition zones were measured at 24, 48, and 72 h to assess antimicrobial efficacy. : The results showed that Endomethasone was the most effective sealer against all tested microorganisms, demonstrating consistent inhibition across all time intervals. MTA Fillapex also exhibited a significant antimicrobial effect, particularly against Streptococcus mutans, with its efficacy increasing over time. AH Plus Jet displayed limited effectiveness, showing significant results only against Staphylococcus aureus. Overall, this study confirms the superior antimicrobial performance of Endomethasone, while the other materials, particularly MTA Fillapex and Sealapex, also showed notable effects in experimental conditions. The antimicrobial activity of all materials, except AH Plus Jet, increased over the 72-h period.
微生物是根管系统感染的主要原因，导致牙髓治疗失败。本体外研究旨在比较四种不同根管封闭剂的抗菌效果：Endomethasone N（法国圣莫尔-德福尔塞Septodont公司）、Sealapex（美国加利福尼亚州奥兰治Kerr公司）、AH Plus Jet（德国康斯坦茨Dentsply DeTrey GmbH公司）和MTA Fillapex（巴西隆德里纳Angelus公司）。使用琼脂扩散法对这些封闭剂针对常见口腔病原体进行测试，这些病原体包括粪肠球菌、金黄色葡萄球菌、大肠杆菌、白色念珠菌和变形链球菌。在24、48和72小时测量抑菌圈以评估抗菌效果。结果表明，Endomethasone是针对所有测试微生物最有效的封闭剂，在所有时间间隔内均表现出持续的抑制作用。MTA Fillapex也表现出显著的抗菌效果，尤其是对变形链球菌，其效果随时间增加。AH Plus Jet显示出有限的有效性，仅对金黄色葡萄球菌有显著效果。总体而言，本研究证实了Endomethasone具有卓越的抗菌性能，而其他材料，特别是MTA Fillapex和Sealapex，在实验条件下也显示出显著效果。除AH Plus Jet外，所有材料的抗菌活性在72小时内均有所增加。
