Chadwick K H, Leenhouts H P
Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Jun;33(6):517-29. doi: 10.1080/09553007814550431.
The recombination type of process, which has been proposed by Resnick to explain the rejoining of radiation-induced DNA double-strand breaks, is combined with the molecular theory of radiation action to provide a description of the formation of chromosomal rearrangments. It is shown that the majority of chromosomal aberration types found at the first mitosis after radiation can be explained on the basis of one radiation-induced DNA double-strand break in the backbone of the unineme chromatid, followed by the enzymatically controlled recombinational process for the rejoining of the double-strand break. The recombinogenic process for the repair of DNA double-strand breaks relies on the close association between the broken DNA double helix and homologous DNA. The homologous nature of repeated DNA base pair sequences is used, in this model, to explain the occurrence of chromosomal exchanges between non-homologous chromosomes. The important role which repetitive DNA plays in the formation of chromosomal rearrangements and in the distribution of 'break-points' found in radiation experiments is discussed.
雷斯尼克提出的用于解释辐射诱导的DNA双链断裂重新连接的重组类型过程，与辐射作用的分子理论相结合，以描述染色体重排的形成。结果表明，辐射后第一次有丝分裂时发现的大多数染色体畸变类型，可以基于单线性染色单体主链中一个辐射诱导的DNA双链断裂，随后通过酶控制的双链断裂重新连接的重组过程来解释。修复DNA双链断裂的重组过程依赖于断裂的DNA双螺旋与同源DNA之间的紧密关联。在这个模型中，重复DNA碱基对序列的同源性质被用来解释非同源染色体之间染色体交换的发生。讨论了重复DNA在染色体重排形成以及辐射实验中发现的“断点”分布中所起的重要作用。
