Friedenreich Christine M, Ruan Yibing, Duha Aalo, Courneya Kerry S
Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Calgary, Alberta, Canada.
Departments of Oncology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
J Obes. 2019 Jan 20;2019:3916416. doi: 10.1155/2019/3916416. eCollection 2019.
BACKGROUND: Exercise interventions can result in weight loss, which is associated with reductions in disease risk. It is unknown how the volume of exercise prescribed in a one-time exercise intervention impacts long-term body fatness. We compared 24-month body fat changes among postmenopausal women previously prescribed 300 versus 150 minutes/week of exercise in a year-long exercise intervention trial. METHODS: The Breast Cancer and Exercise Trial in Alberta (BETA) was a two-centred randomized controlled trial in Alberta, Canada. The trial consisted of a 12-month intervention and 12-month observation period. For the intervention, participants were randomized to either a moderate-volume exercise group (150 min/week) or a high-volume exercise group (300 min/week). Participants in this study were 334 inactive postmenopausal women who had been followed-up to 24 months. The primary outcome for this study was 24-month change in total body fat using dual energy X-ray absorptiometry scans. Other measures included weight, waist and hip circumferences, subcutaneous and intra-abdominal fat from computed tomography scans, and lean mass. Researchers were blinded to randomization group when measuring body fat. RESULTS: Both groups self-reported ∼180 minutes/week moderate-vigorous activity at 24 months. No statistically significant difference was found in total body fat at 24 months between the two groups. Statistically significant effects (comparing high versus moderate groups) were found for BMI (least-square mean change (95% CI): -0.66 (-0.97, -0.36) versus -0.25 (-0.55, 0.05) kg/m, =0.04), waist-to-hip ratio (-0.033 (-0.040, -0.026) versus -0.023 (-0.030, -0.016), =0.05), and subcutaneous abdominal fat area (-32.18 (-39.30, -25.06) versus -22.20 (-29.34, -15.05) cm, =0.04). CONCLUSION: Prescribing 300 versus 150 minutes/week of exercise to inactive postmenopausal women resulted in some long-term greater decreases in measures of body composition but no overall differences in total body fat loss. This trail is registered with NCT01435005.
背景：运动干预可导致体重减轻，这与疾病风险降低相关。一次性运动干预中规定的运动量如何影响长期体脂情况尚不清楚。我们在一项为期一年的运动干预试验中，比较了绝经后女性在之前被规定每周运动300分钟与150分钟的情况下，24个月的体脂变化情况。 方法：艾伯塔省乳腺癌与运动试验（BETA）是加拿大艾伯塔省的一项双中心随机对照试验。该试验包括12个月的干预期和12个月的观察期。对于干预措施，参与者被随机分为中等运动量运动组（每周150分钟）或高运动量运动组（每周300分钟）。本研究的参与者为334名不活跃的绝经后女性，她们被随访至24个月。本研究的主要结局是使用双能X线吸收测定扫描得出的24个月全身脂肪变化。其他测量指标包括体重、腰围和臀围、计算机断层扫描得出的皮下和腹部内脂肪，以及瘦体重。测量体脂时研究人员对随机分组情况不知情。 结果：两组在24个月时自我报告每周进行约180分钟的中等强度至剧烈强度活动。两组在24个月时的全身脂肪量未发现统计学上的显著差异。在体重指数（最小二乘均值变化（95%置信区间）：-0.66（-0.97，-0.36）对-0.25（-0.55，0.05）kg/m²，P=0.04）、腰臀比（-0.033（-0.040，-0.026）对-0.023（-0.030，-0.016），P=0.05）和腹部皮下脂肪面积（-32.18（-39.30，-25.06）对-22.20（-29.34，-15.05）cm²，P=0.04）方面发现了统计学上的显著影响（比较高运动量组与中等运动量组）。 结论：给不活跃的绝经后女性规定每周300分钟与150分钟的运动量，在身体成分测量方面会导致一些长期更明显的下降，但在全身脂肪减少方面没有总体差异。本试验在ClinicalTrials.gov注册号为NCT01435005。
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