Friedenreich Christine M, Wang Qinggang, Shaw Eileen, Heer Emily V, Zhou Ruokun, Brenner Darren R, Courneya Kerry S, Wynne-Edwards Katherine E
Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Calgary, Alberta, Canada.
Departments of Oncology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Prev Med Rep. 2019 Jul 22;15:100960. doi: 10.1016/j.pmedr.2019.100960. eCollection 2019 Sep.
There is epidemiologic and biologic evidence for a role of stress in breast cancer etiology and physical activity mitigates the negative effects of stress. We examined the potential for a dose-response relationship between two volumes of aerobic exercise and biomarkers of chronic stress in post-menopausal women. The Breast Cancer and Exercise Trial in Alberta is a randomized controlled trial with post-menopausal women randomized to either a MODERATE (150 min per week) or HIGH (300 min per week) volume of exercise over a one year intervention period. Fasting serum concentrations of cortisol, cortisone, corticosterone and 11-deoxycortisol at baseline, 12 months (the end of the intervention), and 24 months. Intention-to-treat analyses were performed using general linear models, adjusted for baseline biomarker concentrations. There were modest but non-statistically significant decreases in cortisol (HIGH: -4%, 95% CI: -7%, 2%; MODERATE: -1%, 95%: CI: -14%, 4%) and corticosterone (HIGH: -4%, 95% CI: -12%, 6%; MODERATE: -5%, 95% CI: -14%, 4%) concentrations for both exercise groups between baseline and 12 months, and no difference in cortisone concentrations. Intention-to-treat analysis of 386 (97%) participants showed no statistically significant group differences for changes in biomarker levels at 12 months. Between baseline and 12 months, there were no differences in cortisol or cortisone and, at 24 months all stress hormone levels increased to near-baseline levels with no significant differences between the two intervention groups.
有流行病学和生物学证据表明压力在乳腺癌病因中起作用，而体育活动可减轻压力的负面影响。我们研究了绝经后女性中两种有氧运动运动量与慢性应激生物标志物之间剂量反应关系的可能性。艾伯塔省乳腺癌与运动试验是一项随机对照试验，绝经后女性在一年的干预期内被随机分为适度运动组（每周150分钟）或高强度运动组（每周300分钟）。在基线、12个月（干预结束时）和24个月时测定空腹血清中皮质醇、可的松、皮质酮和11-脱氧皮质醇的浓度。使用一般线性模型进行意向性分析，并对基线生物标志物浓度进行校正。两个运动组在基线和12个月之间，皮质醇（高强度组：-4%，95%置信区间：-7%，2%；适度组：-1%，95%置信区间：-14%，4%）和皮质酮（高强度组：-4%，95%置信区间：-12%，6%；适度组：-5%，95%置信区间：-14%，4%）浓度有适度但无统计学意义的下降，可的松浓度无差异。对386名（97%）参与者的意向性分析显示，12个月时生物标志物水平变化在组间无统计学显著差异。在基线和12个月之间，皮质醇或可的松无差异，在24个月时，所有应激激素水平均升至接近基线水平，两个干预组之间无显著差异。
