Department of Oncology, University of Turin, Turin, Italy.
Breast Unit, Department of Radiology, Cottolengo Hospital, Turin, Italy.
Histol Histopathol. 2019 Aug;34(8):909-915. doi: 10.14670/HH-18-094. Epub 2019 Feb 26.
Eccrine spiradenoma is a rare lesion originating from eccrine sweat glands, with only few cases reported in breast tissue: we here describe for the first time, an eccrine spiradenoma arising in the nipple. An 84 year-old woman with a lesion enlarging her right nipple, showing ulcerations and eczema-like changes of the covering skin, was admitted to our hospital. Surgical excision of the central quadrant with nipple-areola complex was performed, followed by histopathological evaluation which revealed an adenoma with predominantly basaloid epithelial cells. The lesion was composed of tightly packed small and large groups of cells, arranged in diffuse alveolar/pseudorosette formations. The small cells expressed p63 and calponin, while a positive expression of CK7 and CD117 was detected in large cells. After careful and detailed examination, excluding various similar entities, a diagnosis of eccrine spiradenoma has been rendered. Although extremely rare, eccrine spiradenoma should be taken into account in the differential diagnosis of subcutaneous primary breast tumors.
小汗腺螺旋腺瘤是一种罕见的起源于小汗腺的病变，仅在乳腺组织中报道过少数病例：我们在这里首次描述了一种发生在乳头的小汗腺螺旋腺瘤。一位 84 岁的女性，其右侧乳头有一个增大的病变，伴有溃疡和覆盖皮肤的湿疹样改变，被收入我院。进行了中央象限与乳头乳晕复合体的外科切除，随后进行了组织病理学评估，结果显示为以基底样上皮细胞为主的腺瘤。病变由紧密排列的小细胞和大细胞群组成，呈弥漫性肺泡/假玫瑰花结样排列。小细胞表达 p63 和钙调蛋白，而大细胞则检测到 CK7 和 CD117 的阳性表达。经过仔细和详细的检查，排除了各种类似的实体后，诊断为小汗腺螺旋腺瘤。虽然极其罕见，但在鉴别诊断皮下原发性乳腺肿瘤时应考虑小汗腺螺旋腺瘤。
