Hansen N B, Nowicki P T, Miller R R, Malone T, Bickers R G, Menke J A
Pediatr Res. 1986 Feb;20(2):147-50. doi: 10.1203/00006450-198602000-00010.
The effect of prolonged (2 h) hypocarbia on cerebral blood flow, oxygen delivery, extraction, and consumption was studied in eight, 1- to 4-day-old piglets. Hyperventilation to PaCO2 less than 20 mm Hg acutely (30 min) decreased cerebral blood flow and oxygen consumption. Cerebral oxygen consumption was subsequently restored via increases in cerebral blood flow and thus, cerebral oxygen delivery. Cerebral oxygen extraction rose from a normocarbic baseline of 50 to 75% with acute hypocarbia and was maintained at this level. The percent decrease in blood flow to the cerebrum was greater than that to other brain regions during hypocarbia.
在八只1至4日龄仔猪中研究了长时间（2小时）低碳酸血症对脑血流量、氧输送、摄取和消耗的影响。急性（30分钟）过度通气使动脉血二氧化碳分压（PaCO2）低于20毫米汞柱会降低脑血流量和氧消耗。随后通过增加脑血流量以及脑氧输送，脑氧消耗得以恢复。急性低碳酸血症时，脑氧摄取从正常碳酸血症基线的50%升至75%，并维持在这一水平。低碳酸血症期间，流向大脑的血流量减少百分比大于流向其他脑区的血流量减少百分比。
