Department of Radiology, Division of Interventional Radiology.
Department of Surgery, Division of Liver and Pancreas Transplantation, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA.
J Clin Gastroenterol. 2019 May/Jun;53(5):342-349. doi: 10.1097/MCG.0000000000001180.
Portal hypertension, a consequence of end-stage liver disease and liver cirrhosis can lead to significant morbidity and mortality for patients through abnormal fluid accumulation as well as the formation of portosystemic shunts and varices. Treatment of the sequelae of portal hypertension can be achieved through endovascular management by referral to an interventional radiologist on an outpatient or emergent basis as required. Current techniques include the placement of peritoneovenous shunts and tunneled peritoneal drains, the creation of transjugular intrahepatic portosystemic shunts, or the obliteration of shunts via balloon-occluded retrograde transvenous obliteration (BRTO). In addition, newer procedural techniques utilizing vascular plugs and coils have reduced risks of the traditional BRTO procedure. Modified-BRTO procedures, known as plug-assisted and coil-assisted retrograde transvenous obliteration (PARTO and CARTO, respectively) have become the standard of care at many institutions for the treatment of gastric varices and portosystemic shunt-induced hepatic encephalopathy. This review examines the most recent literature of the management of portal hypertension by interventional radiologists, evaluating treatment options as well as the clinical and technical outcomes of TIPS, peritoneovenous shunts, tunneled peritoneal drains, BRTOs, and modified-BRTOs as well as future directions in the development of procedural techniques.
门静脉高压症是终末期肝病和肝硬化的后果,可导致患者出现异常体液积聚以及门体分流和静脉曲张,从而导致严重的发病率和死亡率。门静脉高压症的后遗症可以通过介入放射科医生的血管内治疗来治疗,根据需要在门诊或紧急情况下转诊。目前的技术包括腹膜静脉分流术和经皮隧道引流管、经颈静脉肝内门体分流术的创建,或者通过球囊阻塞逆行经静脉闭塞术(BRTO)闭塞分流。此外,利用血管塞和线圈的新技术降低了传统 BRTO 手术的风险。新型 BRTO 手术,称为塞辅助和线圈辅助逆行经静脉闭塞术(PARTO 和 CARTO),已成为许多机构治疗胃静脉曲张和门体分流性肝性脑病的标准治疗方法。这篇综述探讨了介入放射学家治疗门静脉高压症的最新文献,评估了 TIPS、腹膜静脉分流术、经皮隧道引流管、BRTO 和改良 BRTO 的治疗选择以及手术技术发展的未来方向。