Department of Surgery, SUNY Upstate Medical University, Syracuse, New York.
Shock. 2019 Dec;52(6):568-576. doi: 10.1097/SHK.0000000000001326.
Toll-like receptors are transmembrane proteins which sense and transmit infectious and inflammatory responses to the cells expressing them. Therapeutic strategies for the blockade of excessive Toll-like receptor signaling are being actively pursued for several diseases. Recently, Sparstolonin B, isolated from Chinese herb, which suppresses selectively Toll-like receptors has been studied in various inflammatory models. The objective of this review is to summarize the current literature regarding the use of Sparstolonin B in various in vitro and in vivo studies and to provide an overview regarding the potential use of this agent in different inflammatory diseases. Additionally, the current knowledge regarding the role of Toll-like receptors in inflammatory disease and the usage of various Toll-like receptor antagonists will be summarized. Based on our review, we believe Sparstolonin B could serve as a potential therapeutic agent for treatment of Toll-like receptor-mediated inflammatory disorders.
Toll 样受体是一种跨膜蛋白，能够感知和传递感染和炎症反应到表达它们的细胞。目前正在积极研究针对多种疾病的过度 Toll 样受体信号通路阻断的治疗策略。最近，从中国草药中分离出的 Sparstolonin B 被研究用于各种炎症模型，它选择性地抑制 Toll 样受体。本综述的目的是总结 Sparstolonin B 在各种体外和体内研究中的应用，并概述该药物在不同炎症性疾病中的潜在用途。此外，还将总结目前关于 Toll 样受体在炎症性疾病中的作用以及各种 Toll 样受体拮抗剂的应用的知识。基于我们的综述，我们认为 Sparstolonin B 可能成为治疗 Toll 样受体介导的炎症性疾病的潜在治疗药物。
