Sakanashi M, Kato T, Miyamoto Y, Nakasone J, Aniya Y
Pharmacology. 1986;32(1):11-7. doi: 10.1159/000138147.
Effects of diltiazem on isolated ureter and coronary artery of the dog were compared with those of glycerol trinitrate (GTN). Diltiazem (DZ) (10(-9)-10(-6) M) decreased the force and frequency of ureteral rhythmic contractions evoked by potassium or phenylephrine in a concentration-dependent manner, and relaxed potassium-contracted coronary artery strips. The dose dependence of the inhibitory effects of diltiazem was similar on the ureter and coronary artery. GTN (10(-7)-10(-5) M) also showed similar inhibitory effects, but these were more pronounced on the coronary artery than on the ureter.
