Bradley C M, Nicholson A N
Psychopharmacology (Berl). 1986;88(1):112-4. doi: 10.1007/BF00310524.
Effects of 5 mg/kg diazepam given once a week for several weeks to drug-naive and drug-experienced monkeys were studied on a spatial delayed-alternation task. In both groups response latency was increased and the number of correct responses was reduced. The effects were consistent over weeks in the experienced monkeys, but in the naive monkeys there were greater initial effects on response latency and on repeat errors, and these lessened over 2-3 weeks. Thereafter, effects resembled those observed in the experienced group. Results are discussed in terms of the possible factors involved in the development and persistence of tolerance to benzodiazepines.
对未曾使用过药物和有药物使用经验的猴子，每周一次给予5毫克/千克地西泮，持续数周，研究其对空间延迟交替任务的影响。在两组中，反应潜伏期均增加，正确反应次数减少。有经验的猴子在数周内效果一致，但未使用过药物的猴子在反应潜伏期和重复错误方面最初的影响更大，且这些影响在2至3周内减弱。此后，其效果类似于在有经验的组中观察到的效果。根据与苯二氮䓬类药物耐受性的发展和持续相关的可能因素对结果进行了讨论。
