贝宁科托努治愈肺结核患者的肺功能损害患病率。
Prevalence of lung function impairment in cured pulmonary tuberculosis patients in Cotonou, Benin.
机构信息
Programme national contre la Tuberculose, Centre national hospitalo-universitaire de Pneumophtisiologie, Cotonou, Benin, International Health, Institut de Santé Publique Epidémiologie Développement (ISPED), Université de Bordeaux, Bordeaux.
Programme national contre la Tuberculose, Centre national hospitalo-universitaire de Pneumophtisiologie, Cotonou, Benin.
出版信息
Int J Tuberc Lung Dis. 2019 Feb 1;23(2):195-202. doi: 10.5588/ijtld.18.0234.
SETTING
National teaching hospital for the management of respiratory diseases, Cotonou, Benin.
OBJECTIVE
- To estimate the prevalence of lung function impairment (LFI) and associated factors in patients cured of pulmonary tuberculosis (PTB); and 2) to determine the link between human immunodeficiency virus (HIV) infection and LFI occurrence.
DESIGN
We performed a cross-sectional study in cured patients with smear-positive TB (PTB+) treated between 2012 and 2015. We recruited two control groups of 70 HIV-infected (HIV+/TB-) and 70 HIV-negative participants without TB (HIV-/TB-). We performed spirometry in all participants to identify LFI (obstructive, restrictive or mixed) and the 6-min walk test (6-MWT) in PTB+ participants. We assessed the factors associated with LFI using logistic regression.
RESULTS
Of 4711 subjects with PTB, 241 were contacted and 189 were included. The median age was 37 years; 128 (68.0%) were male. Overall, 85 cured PTB+ patients had LFI (45.0%). Extent of initial radiological lesions, time between symptom onset and treatment, and female sex were independently associated with LFI. Fifty-five (29.1%) cured PTB+ patients had an abnormal 6-MWT; those with LFI had a higher risk of poor exercise tolerance (OR 2.23; interquartile range 1.16-4.30). We did not find any association between HIV infection and LFI.
CONCLUSION
LFI is very common in cured PTB+ patients from Benin and significantly impacts exercise tolerance.
背景
贝宁科托努国家教学医院，呼吸疾病管理。
目的
1）评估已治愈肺结核（PTB）患者的肺功能损害（LFI）患病率及其相关因素；2）确定人类免疫缺陷病毒（HIV）感染与 LFI 发生之间的联系。
设计
我们对 2012 年至 2015 年间接受治疗的涂片阳性肺结核（PTB+）治愈患者进行了一项横断面研究。我们招募了两组对照组，每组 70 名 HIV 感染（HIV+/TB-）和 70 名无结核的 HIV 阴性参与者（HIV-/TB-）。我们对所有参与者进行了肺活量测定以确定 LFI（阻塞性、限制性或混合性），并对 PTB+参与者进行了 6 分钟步行测试（6-MWT）。我们使用逻辑回归评估与 LFI 相关的因素。
结果
在 4711 名患有 PTB 的患者中，我们联系了 241 名患者，其中 189 名患者被纳入研究。中位年龄为 37 岁；128 名（68.0%）为男性。总体而言，85 名治愈的 PTB+患者存在 LFI（45.0%）。初始影像学病变的严重程度、症状出现与治疗之间的时间以及女性均与 LFI 独立相关。55 名（29.1%）治愈的 PTB+患者的 6-MWT 异常；存在 LFI 的患者运动耐量较差的风险更高（OR 2.23；四分位间距 1.16-4.30）。我们未发现 HIV 感染与 LFI 之间存在任何关联。
结论
LFI 在贝宁已治愈的 PTB+患者中非常常见，且显著影响运动耐量。
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