Queen Elizabeth University Hospital, Glasgow, Scotland.
Medical Research Council University of Glasgow Centre for Virus Research, Glasgow, Scotland.
Int J Tuberc Lung Dis. 2019 Feb 1;23(2):239-240. doi: 10.5588/ijtld.18.0255.
We present a case of pulmonary tuberculosis treated with a rifampicin (RMP) containing regimen, which led to marked haemolysis and acute kidney injury. The patient was shown to have RMP-induced haemolysis on detailed immunological testing. RMP is described as a rare cause of drug-induced haemolysis in the literature. However, it is a widely used drug and this complication may be severe. RMP-induced haemolysis precludes further treatment with the drug. Clinicians should consider this possibility and seek advice if patients on RMP develop haemolysis.
我们报告了一例利福平(RMP)含药方案治疗的肺结核病例,该方案导致明显的溶血性贫血和急性肾损伤。详细的免疫检测显示该患者存在 RMP 诱导的溶血性贫血。RMP 在文献中被描述为一种罕见的药物诱导溶血性贫血的原因。然而,它是一种广泛使用的药物,这种并发症可能很严重。RMP 诱导的溶血性贫血排除了进一步使用该药物治疗的可能。如果接受 RMP 治疗的患者发生溶血性贫血,临床医生应考虑这种可能性并寻求建议。