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Haemolytic anaemia induced by flutamide: a case report.氟他胺致溶血性贫血 1 例报告
Eur J Hosp Pharm. 2023 Mar;30(e1):e109-e111. doi: 10.1136/ejhpharm-2021-002936. Epub 2021 Aug 2.
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本文引用的文献

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A case report of serious haemolysis in a glucose-6-phosphate dehydrogenase-deficient COVID-19 patient receiving hydroxychloroquine.葡萄糖-6-磷酸脱氢酶缺乏症 COVID-19 患者接受羟氯喹后发生严重溶血的病例报告。
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A case of rifampicin-induced haemolysis.利福平致溶血性贫血 1 例。
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The effects of flutamide on cell-cell junctions in the testis, epididymis, and prostate.氟他胺对睾丸、附睾和前列腺细胞连接的影响。
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Flutamide-induced hepatotoxicity: ethical and scientific issues.氟他胺诱导的肝毒性：伦理和科学问题。
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Piperacillin-induced mild haemolytic anaemia in a 44-year-old patient with cystic fibrosis.哌拉西林诱发一名44岁囊性纤维化患者出现轻度溶血性贫血。
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Prostate cancer.前列腺癌。
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Recent approaches for reducing hemolytic activity of chemotherapeutic agents.近期降低化疗药物溶血性的方法。
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Adverse drug reactions during ceftriaxone treatment can cause severe hemolysis.
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Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury.Th2 细胞因子在氟他胺诱导的急性肝损伤小鼠模型中的作用。
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氟他胺致溶血性贫血 1 例报告

Haemolytic anaemia induced by flutamide: a case report.

机构信息

Department of Pharmacy, Ningbo City First Hospital, Ningbo, Zhejiang, China.

Department of Pharmacy, Ningbo City First Hospital, Ningbo, Zhejiang, China

出版信息

Eur J Hosp Pharm. 2023 Mar;30(e1):e109-e111. doi: 10.1136/ejhpharm-2021-002936. Epub 2021 Aug 2.

DOI:10.1136/ejhpharm-2021-002936
PMID:34341002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10086728/
Abstract

Flutamide-induced haemolytic anaemia is rare but can be fatal. We describe the case of an 88-year-old man with prostatic carcinoma who, in addition to clinically obvious jaundice, developed haemolytic anaemia after undergoing treatment with flutamide for 5 days. When flutamide was replaced with temporary adrenocortical hormone treatment and blood transfusion, the blood indices and liver function of the patient improved gradually. We emphasise the need for routine monitoring of blood counts for patients undergoing flutamide treatment, and highlight the importance of discontinuing flutamide immediately when haemolytic anaemia occurs.

摘要

氟他胺引起的溶血性贫血虽少见，但可致命。我们描述了一例 88 岁的前列腺癌患者，在接受氟他胺治疗 5 天后，除了临床上明显的黄疸外，还发生了溶血性贫血。当用临时肾上腺皮质激素治疗和输血代替氟他胺时，患者的血液指标和肝功能逐渐改善。我们强调了对接受氟他胺治疗的患者进行常规血细胞计数监测的必要性，并强调了当发生溶血性贫血时应立即停止使用氟他胺。