Department of Pharmacy, Ningbo City First Hospital, Ningbo, Zhejiang, China.
Department of Pharmacy, Ningbo City First Hospital, Ningbo, Zhejiang, China
Eur J Hosp Pharm. 2023 Mar;30(e1):e109-e111. doi: 10.1136/ejhpharm-2021-002936. Epub 2021 Aug 2.
Flutamide-induced haemolytic anaemia is rare but can be fatal. We describe the case of an 88-year-old man with prostatic carcinoma who, in addition to clinically obvious jaundice, developed haemolytic anaemia after undergoing treatment with flutamide for 5 days. When flutamide was replaced with temporary adrenocortical hormone treatment and blood transfusion, the blood indices and liver function of the patient improved gradually. We emphasise the need for routine monitoring of blood counts for patients undergoing flutamide treatment, and highlight the importance of discontinuing flutamide immediately when haemolytic anaemia occurs.
氟他胺引起的溶血性贫血虽少见,但可致命。我们描述了一例 88 岁的前列腺癌患者,在接受氟他胺治疗 5 天后,除了临床上明显的黄疸外,还发生了溶血性贫血。当用临时肾上腺皮质激素治疗和输血代替氟他胺时,患者的血液指标和肝功能逐渐改善。我们强调了对接受氟他胺治疗的患者进行常规血细胞计数监测的必要性,并强调了当发生溶血性贫血时应立即停止使用氟他胺。