Institute of Musculoskeletal Medicine, University Hospital Münster, Münster, Germany.
Osteoarthritis Cartilage. 2019 Mar;27(3):365-370. doi: 10.1016/j.joca.2018.10.005. Epub 2018 Oct 25.
This Year in Review highlights a selection of articles published between the 2017 and 2018 Osteoarthritis Research Society International (OARSI) World Congress meetings within the field of osteoarthritis biology, presented at OARSI 2018. Selected articles were obtained from a PubMed search covering cartilage, subchondral bone, inflammation, ageing, pain and animal models. Studies focused on biomechanics, biomarkers, genetics and epigenetics, imaging and clinical studies were excluded due to their coverage in other articles within the OARSI Year in Review series. Significant themes including the role of progenitor cells in cartilage homeostasis and repair, novel signalling mechanisms controlling chondrocyte phenotypic stability and the influence of disrupted or senescent chondrocytes were identified and are discussed in this review. Overarching conclusions derived from these study areas indicate that promising avenues of intervention are on the horizon, however further understanding is required in order to target therapeutic treatments to suitable patient subgroups and disease stages.
这篇年度综述精选了在骨关节炎研究协会国际（OARSI）2017 年至 2018 年世界大会期间发表的、与骨关节炎生物学领域相关的文章，这些文章均在 2018 年 OARSI 会议上展示。综述中选取的文章来源于一个涵盖软骨、软骨下骨、炎症、衰老、疼痛和动物模型的 PubMed 搜索。由于其他 OARSI 年度综述系列中的文章已经涵盖了生物力学、生物标志物、遗传学和表观遗传学、影像学和临床研究，因此本文排除了这些研究。综述中讨论了一些重要主题，包括祖细胞在软骨稳态和修复中的作用、控制软骨细胞表型稳定性的新信号机制，以及受损或衰老软骨细胞的影响。从这些研究领域得出的总体结论表明，有希望的干预途径即将出现，但为了将治疗方法靶向适用于合适的患者亚组和疾病阶段，还需要进一步的理解。
