Alashraf Abdul Rahman, Lau Seng Fong, Khor Kuan Hua, Khairani-Bejo Siti, Bahaman Abdul Rani, Roslan Mohd Azri, Rahman Mohd Sabri Abdul, Goh Soon Heng, Radzi Rozanaliza
Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Top Companion Anim Med. 2019 Mar;34:10-13. doi: 10.1053/j.tcam.2018.12.002. Epub 2018 Dec 7.
Leptospirosis is one of the most widespread zoonotic diseases and despite extensive research, there is still a paucity of information regarding this disease in cats. The aim of this study was to investigate the prevalence of leptospirosis among the shelter cat population in Malaysia and to determine the most common infective Leptospira serogroups among them. Blood samples were collected from a total of 110 cats from 4 different shelters. The sampled cats appeared healthy, with minimal evidence of feline upper respiratory disease. The Microscopic Agglutination Test was used to detect anti-Leptospira antibodies against 20 pathogenic serovars. Based on a cut-off antibody titer of ≥1:100, 20 of 110 sheltered cats, showed presence of anti-Leptospira antibodies against at least 1 serovar. The serodetection of leptospirosis was 18.18% (95% confidence interval 12.09-26.42). The most commonly detected serogroups were Bataviae, Javanica, and Ballum, with antibody titers ranging from 1:100 to 1:1600. Knowledge of the predominant infective serovars in hosts worldwide and regionally is imperative for understanding the epidemiology of this zoonotic disease. Serosurveillance is the first step in this process. Further studies are warranted for investigation of urinary shedding in naturally infected cats with leptospirosis, using Polymerase chain reaction (PCR) and organism isolation followed by serovars identification.
钩端螺旋体病是最广泛传播的人畜共患病之一，尽管进行了广泛研究，但关于猫感染这种疾病的信息仍然匮乏。本研究的目的是调查马来西亚收容所猫群中钩端螺旋体病的患病率，并确定其中最常见的感染性钩端螺旋体血清群。从4个不同收容所的总共110只猫中采集了血样。所采样的猫看起来健康，几乎没有猫上呼吸道疾病的迹象。采用显微镜凝集试验检测针对20种致病性血清型的抗钩端螺旋体抗体。基于≥1:100的临界抗体滴度，110只收容猫中有20只显示存在针对至少1种血清型的抗钩端螺旋体抗体。钩端螺旋体病的血清学检测率为18.18%（95%置信区间12.09 - 26.42）。最常检测到的血清群是巴达维亚型、爪哇型和拜伦型，抗体滴度范围为1:100至1:1600。了解全球和区域宿主中主要的感染性血清型对于理解这种人畜共患病的流行病学至关重要。血清学监测是这一过程的第一步。有必要进一步开展研究，利用聚合酶链反应（PCR）和病原体分离随后进行血清型鉴定，调查自然感染钩端螺旋体病的猫的尿液排菌情况。
