Chauhan Abhishek, Webb Gwilym, Ferguson James
NIHR Birmingham Biomedical Research Centre, United Kingdom; Liver unit, University Hospitals Birmingham, United Kingdom; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
Liver unit, University Hospitals Birmingham, United Kingdom; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
Clin Res Hepatol Gastroenterol. 2019 Nov;43(6):649-657. doi: 10.1016/j.clinre.2019.01.005. Epub 2019 Feb 23.
Hepatitis E virus (HEV) typically causes an acute, self-limiting hepatitis and is among the commonest cause of such presentations. Hepatitis E viral infection is also increasingly recognized as a cause of chronic hepatitis amongst the immunocompromised, particularly amongst solid organ transplant recipients. Chronic HEV infection remains an underdiagnosed disease and chronic infection can lead to rapidly progressive liver fibrosis and cirrhosis. This review examines current understanding of the HEV. We illustrate typical clinical presentations, management strategies [(based upon guidelines from both the British Transplant Society (BTS) and European Association for the study of liver (EASL)] and outcomes of HEV infection in different cohorts of patients by highlighting select transplant and non-transplant patient cases, from one of the largest tertiary Hepatology centres in Europe.
戊型肝炎病毒（HEV）通常引起急性自限性肝炎，是此类病症最常见的病因之一。戊型肝炎病毒感染也越来越被认为是免疫功能低下人群，尤其是实体器官移植受者中慢性肝炎的病因。慢性戊型肝炎病毒感染仍是一种诊断不足的疾病，慢性感染可导致快速进展的肝纤维化和肝硬化。本综述探讨了目前对戊型肝炎病毒的认识。我们通过重点介绍欧洲最大的三级肝病中心之一的部分移植和非移植患者病例，阐述了戊型肝炎病毒感染在不同患者群体中的典型临床表现、管理策略（基于英国移植学会（BTS）和欧洲肝脏研究协会（EASL）的指南）及预后。
