食用肉类是戊型肝炎病毒感染的主要风险因素。
Meat consumption is a major risk factor for hepatitis E virus infection.
作者信息
Slot Ed, Zaaijer Hans L, Molier Michel, Van den Hurk Katja, Prinsze Femmeke, Hogema Boris M
机构信息
Sanquin Research, Department of Blood-borne infections, Amsterdam, the Netherlands.
Academic Medical Center, Department of Clinical Virology (CINIMA), Amsterdam, the Netherlands.
出版信息
PLoS One. 2017 Apr 27;12(4):e0176414. doi: 10.1371/journal.pone.0176414. eCollection 2017.
BACKGROUND
The incidence of autochthonous hepatitis E virus genotype 3 (HEV gt3) infections in Western Europe is high. Although pigs are a major reservoir of the virus, the exact sources and transmission route(s) of HEV gt3 to humans remain unclear.
METHODS
To determine the role of meat consumption at a population level, the seroprevalence of anti-HEV IgG antibodies was compared between Dutch blood donors with a vegetarian lifestyle and donors who consume meat on a daily basis.
RESULTS
The age-weighted anti-HEV IgG seroprevalence among donors not eating meat was significantly lower than among meat-eating donors (12.4% vs 20.5%, p = 0.002). For both groups the prevalence strongly increased with age and the difference in prevalence was apparent for all age groups.
CONCLUSIONS
Compared with meat-eating donors, the incidence of HEV infection is significantly lower among donors not eating meat, indicating that meat consumption is a major risk factor for HEV infection.
背景
在西欧，戊型肝炎病毒3型（HEV gt3）本土感染的发生率很高。尽管猪是该病毒的主要宿主，但HEV gt3感染人类的确切来源和传播途径仍不清楚。
方法
为了在人群层面确定肉类消费的作用，比较了荷兰素食生活方式的献血者和每天食用肉类的献血者中抗HEV IgG抗体的血清阳性率。
结果
不食用肉类的献血者中年龄加权抗HEV IgG血清阳性率显著低于食用肉类的献血者（12.4%对20.5%，p = 0.002）。两组的患病率均随年龄大幅增加，且所有年龄组的患病率差异均很明显。
结论
与食用肉类的献血者相比，不食用肉类的献血者中HEV感染的发生率显著更低，这表明肉类消费是HEV感染的主要危险因素。
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