肾脏花生四烯酸代谢的生物化学与药理学

Biochemistry and pharmacology of renal arachidonic acid metabolism.

作者信息

Morrison A R

出版信息

Am J Med. 1986 Jan 17;80(1A):3-11. doi: 10.1016/0002-9343(86)90927-7.

Abstract

Arachidonic acid is metabolized to prostaglandin, lipoxygenase products, and products of the microsomal cytochrome P-450 enzymes of the kidney. The distribution of the metabolizing enzymes and their regulation and pharmacologic manipulation are reviewed. The mechanisms of release of arachidonic acid from membrane lipids through a surface-mediated receptor mechanism are also discussed. The localization of the various enzymes and product formation may have profound effects on glomerular filtration, renal blood flow, and electrolyte excretion. Therefore, an understanding of the potential sites of inhibition of the nonsteroidal anti-inflammatory drugs is important in assessing their effects on renal function.

摘要

花生四烯酸可代谢生成前列腺素、脂氧合酶产物以及肾脏微粒体细胞色素P-450酶的产物。本文综述了这些代谢酶的分布、调控及其药理作用。同时也讨论了通过表面介导的受体机制从膜脂中释放花生四烯酸的机制。各种酶的定位和产物形成可能对肾小球滤过、肾血流量和电解质排泄产生深远影响。因此，了解非甾体抗炎药潜在的抑制位点对于评估它们对肾功能的影响很重要。