Paris P M, Kaplan R M, Stewart R D, Weiss L D
Ann Emerg Med. 1986 Feb;15(2):171-3. doi: 10.1016/s0196-0644(86)80014-2.
Sublingual nitroglycerin 0.8 mg every five minutes for a total of 4.8 mg was administered to 11 healthy volunteers. One volunteer had to withdraw due to a hypotensive bradycardic reaction after 2.4 mg. In the remaining subjects, methemoglobinemia over the next hour never significantly increased from baseline levels, reaching a peak of only 0.71%. We conclude that commonly used doses of sublingual nitroglycerin do not induce significant methemoglobinemia and that nitroglycerin would not be useful in the treatment of cyanide poisoning.
对11名健康志愿者给予舌下含服硝酸甘油，每5分钟0.8毫克，总量为4.8毫克。一名志愿者在服用2.4毫克后因低血压性心动过缓反应而退出。在其余受试者中，接下来一小时内高铁血红蛋白血症从未显著高于基线水平，仅达到0.71%的峰值。我们得出结论，常用剂量的舌下含服硝酸甘油不会诱发显著的高铁血红蛋白血症，且硝酸甘油对氰化物中毒治疗无效。
